Heterogeneous and anisotropic diffusion in the developing rat spinal cord

Neuroreport
S ProkopováE Syková

Abstract

Extrasynaptic transmission is mediated by the diffusion of transmitters, through the extracellular space (ECS) to receptors on neurons and glia. The three-dimensional diffusion of tetramethylammonium (mol. wt 74.1 kDa) was investigated in the isolated rat spinal cord at postnatal days 4-20. The diffusion parameters of the ECS, volume fraction alpha, tortuosity lambda (lambda2 = free/apparent diffusion coefficient in tissue) and nonspecific uptake k', were different in gray and white matter. In both gray and white matter, alpha decreased with neuronal development and gliogenesis by about 15% while lambda significantly increased. Diffusion in gray matter remained isotropic (lambda = 1.65), while in white matter it became anisotropic, i.e. easier along the fibers (lambda = 1.38) than across the fibers (lambda = 1.80). Anisotropy increased in the second postnatal week, during pronounced myelination. In myelinated tissue, preferential diffusion of neuroactive substances occurs along the axons.

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Citations

Nov 9, 2000·Journal of Neuroscience Research·S Prokopová-Kubinová, E Syková
Sep 22, 2005·Acta Neuropathologica·Josef Zamecnik
Jul 13, 2006·Annals of Biomedical Engineering·Malisa SarntinoranontThomas H Mareci
Dec 25, 2009·Medical & Biological Engineering & Computing·Jung Hwan KimMalisa Sarntinoranont
Jun 10, 2004·Neurochemistry International·Eva Syková
May 14, 1999·Trends in Pharmacological Sciences·M ZoliK Fuxe
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Mar 25, 2000·Neurochemistry International·E Syková, A Chvátal
Feb 10, 1999·Experimental Gerontology·E SykováZ Simonová
Aug 13, 2004·Neuropathology and Applied Neurobiology·J ZámecníkE Syková
Jun 19, 1998·Neuroreport·T MazelE Syková
Jul 31, 2009·Journal of Biomechanical Engineering·Jung Hwan KimMalisa Sarntinoranont
Oct 17, 2008·Physiological Reviews·Eva Syková, Charles Nicholson
Aug 1, 1998·Journal of Biomaterials Science. Polymer Edition·S WoerlyE Syková
Sep 17, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Lýdia Vargová, Eva Syková
Feb 21, 2003·Glia·Lýdia VargováEva Syková
Jun 14, 2008·Journal of Biomechanics·Andreas A LinningerRichard D Penn
Apr 28, 2012·The European Journal of Neuroscience·Josef ZamecnikLydia Vargova
May 22, 2007·Neurochemistry International·Eva Syková, Lýdia Vargová
Sep 21, 2010·Journal of Applied Polymer Science. Applied Polymer Symposium·Sung Jin LeeMalisa Sarntinoranont
Jun 6, 2003·Journal of Neurophysiology·Frank RichterHans-Georg Schaible
Jun 10, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Malisa SarntinoranontPaul F Morrison
May 1, 2018·Fluids and Barriers of the CNS·Shinuo LiuMarcus A Stoodley

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