Heterogeneous beta2-adrenoceptor expression and dilation in coronary arterioles across the left ventricular wall

Circulation
Travis W HeinLih Kuo

Abstract

Previous in vivo studies have shown that beta-adrenoceptor agonists cause a redistribution of coronary flow away from the subendocardium; however, the underlying mechanism remains uncertain. We tested the hypothesis that a heterogeneous distribution of beta-adrenoceptors and their vasomotor responses exists in the coronary microcirculation across the left ventricular wall. Porcine subepicardial and subendocardial arterioles (<100 microm) were isolated from the left ventricle and pressurized for in vitro study of vasodilation to the nonselective beta-adrenoceptor agonist isoproterenol and the selective beta2-adrenoceptor agonist procaterol. Both vessel types developed a similar level of basal tone and dilated to isoproterenol and procaterol. However, subepicardial arterioles exhibited a much higher sensitivity and greater dilation capacity to both agonists. The isoproterenol-induced vasodilations were inhibited by glibenclamide, an ATP-sensitive potassium (K(ATP)) channel blocker. In contrast to isoproterenol, dilations of subepicardial and subendocardial arterioles to pinacidil, a K(ATP) channel opener, were similar. In both vessel types, isoproterenol-induced dilation was inhibited by the beta2-adrenoceptor blocker ICI-118,551...Continue Reading

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Citations

Jan 17, 2009·Journal of Human Hypertension·C SunT Y Wong
Dec 21, 2007·Nature Clinical Practice. Cardiovascular Medicine·Alexander R LyonSian E Harding
Jul 5, 2013·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Syana M SarnaikKathryn A Felmet
Jun 29, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yun ShiChun Jiang
Mar 11, 2011·World Journal of Cardiology·Cuihua Zhang
Nov 1, 2011·Journal of Molecular and Cellular Cardiology·Dirk J DunckerDaphne Merkus
Jan 9, 2016·Respiratory Medicine Case Reports·Tehila A SaadiaHaesoon Lee
May 5, 2009·Journal of Molecular and Cellular Cardiology·Travis W HeinLih Kuo
Jul 28, 2015·Journal of Molecular and Cellular Cardiology·Naris ThengchaisriLih Kuo
Nov 28, 2017·Allergy, Asthma & Immunology Research·Wei YangYasutaka Kurata
Jul 16, 2008·Physiological Reviews·Dirk J Duncker, Robert J Bache
Dec 26, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Fen GaoDaphne Merkus

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