Heterogeneous characteristics of mitral cells in the rat olfactory bulb

Brain Research Bulletin
G Z YuK Seto

Abstract

The spontaneous firing activity of olfactory bulb mitral cells and their response to intrabulbar infusion of GABAA receptor antagonist bicuculline were studied in ovariectomized, urethane-anesthetized female rats. Mitral cells recorded in the absence of specific stimuli and nasal airflow displayed three distinct patterns of spontaneous firing: high-frequency bursts with relatively long silent periods; high-frequency bursts without accurately defined silent periods; continuous. Infusion of bicuculline (0.2 nmol) into the bulb yielded inconsistent results on spontaneous firing and its inhibition evoked by electrical stimulation of the lateral olfactory tract. Of 32 cells tested, the spontaneous firing rate increased for 24, decreased for 6, and was not altered for 2. Likewise, of 18 cells tested, the poststimulus inhibitory period shortened for 12, lengthened for 4, and not altered for 2. An increased dose (0.4 nmol) of bicuculline produced dose-response relationships simply without any reversal effect. These results suggest that the heterogeneity of mitral cells exists in the context of local interneuronal circuitry in the bulb.

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Citations

Sep 14, 2011·PloS One·Josif StakicEdwin R Griff
Jan 6, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Matthew E PhillipsG M SHEPHERD
Aug 17, 2010·Brain Research·Romanita NicaEdwin R Griff
Oct 5, 2014·Physiological Reports·Gareth LengMike Ludwig
Sep 15, 2020·The Journal of Physiology·Johanna K KostkaIleana L Hanganu-Opatz
May 1, 1996·Journal of Neurobiology·T A ChristensenJ G Hildebrand

Related Concepts

Nerve Impulses
Metazoa
Bicuculline
Electric Stimulation Technique
Accessory Olfactory Bulb
Rats, Wistar
Rats, Laboratory

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