Heterogeneous distribution of myocardial steatosis--an ex vivo evaluation.

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Chia-Ying LiuCharles Steenbergen

Abstract

Myocardial fat accumulation could occur in diseased hearts. The degree of heterogeneity is unknown because accurate assessment is difficult using conventional proton magnetic resonance spectroscopy techniques in a beating heart. The purpose of this study was to characterize the distribution of intramyocellular lipid content and to determine its association with disease characteristics. Proton magnetic resonance spectroscopy was performed on formalin-fixed slices of human hearts at various circumferential locations (N = 55). Twenty-nine percent of the hearts had the highest fat content measured in the septum, followed by posterior (27%), lateral (26%), and anterior (18%) wall. Age was significantly correlated with the mean fat percentages (r2 = 0.12, P = 0.007). Those who died from cardiovascular disease demonstrated significantly higher and more heterogeneous fat distribution than those who did not (1.62% ± 1.1% vs. 0.59% ± 0.4%, P = 0.002). In summary, septal fat content is representative of mean fat percentage. Fat content increases with age; fat distribution may be heterogeneous when associated with cardiovascular disease.

References

Aug 11, 1993·Biochimica Et Biophysica Acta·M C MaddenP E Wolkowicz
Jan 4, 1998·Journal of Magnetic Resonance·L Vanhamme Van Huffel S
Apr 4, 2001·The Journal of Clinical Investigation·H C ChiuJ E Schaffer
Apr 12, 2001·Seminars in Liver Disease·E S Siegelman, M A Rosen
Jun 8, 2001·Magma·A NaressiD Graveron-Demilly
Jan 18, 2003·Biochimica Et Biophysica Acta·Roger H Unger, Lelio Orci
Feb 21, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Lidia S SzczepaniakRonald G Victor
Jul 4, 2003·Current Opinion in Lipidology·Jean E Schaffer
Jul 17, 2003·Endocrinology·Christina ChristoffersenLars B Nielsen
Jan 6, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Scott B ReederNorbert J Pelc
Jun 24, 2005·American Journal of Physiology. Endocrinology and Metabolism·Jason S ReingoldLidia S Szczepaniak
Apr 6, 2006·Annals of Internal Medicine·Jonathan M McGavockUNKNOWN American College of Physicians and the American Physiological Society
Aug 24, 2006·The Journal of Clinical Endocrinology and Metabolism·Mikko KankaanpääPatricia Iozzo
Aug 19, 2007·Circulation·Jonathan M McGavockLidia S Szczepaniak
Dec 8, 2007·Journal of Magnetic Resonance Imaging : JMRI·Clare P BernardChristian M Langton
Feb 29, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D HernandoZ-P Liang
May 22, 2008·European Heart Journal·Rutger W van der MeerHildo J Lamb
Nov 22, 2008·Journal of the American College of Cardiology·Luuk J RijzewijkHildo J Lamb
Nov 22, 2008·Journal of the American College of Cardiology·Jason B Lindsey, Steven P Marso
Dec 20, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Peter KellmanAndrew E Arai
Apr 8, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Chia-Ying LiuDavid A Bluemke

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Citations

Feb 7, 2016·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Pen-An LiaoKoon-Kwan Ng
May 27, 2015·NMR in Biomedicine·Petronella A van EwijkM Eline Kooi
Mar 2, 2013·Journal of the American College of Cardiology·Bénédicte GaboritAnne Dutour
Apr 26, 2014·Heart·Marit GranérMarja-Riitta Taskinen

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