Heterogeneous estimates of influenza virus types A and B in the elderly: Results of a meta-regression analysis

Influenza and Other Respiratory Viruses
Donatella PanattoDaniela Amicizia

Abstract

Influenza has many age-dependent characteristics. A previous systematic review of randomized controlled trials showed that the detection rate of influenza B was higher in children than in non-elderly adults. However, no comprehensive reviews have targeted the elderly, who carry the main burden of disease. We aimed to quantify the relative detection rates of virus types A and B among the elderly, to identify factors affecting these proportions, and to compare type distribution among seniors and younger age-classes. A comprehensive literature search was conducted to identify multiseason studies reporting A and B virus type distributions in the elderly. A random-effects meta-analysis was planned to quantify the prevalence of type B among elderly subjects with laboratory-confirmed influenza. Meta-regression was then applied to explain the sources of heterogeneity. Across 27 estimates identified, the type B detection rate among seniors varied from 5% to 37%. Meta-analysis was not feasible owing to high heterogeneity (I2  = 98.5%). Meta-regression analysis showed that study characteristics, such as number of seasons included, hemisphere, and setting, could have contributed to the heterogeneity observed. The final adjusted model showe...Continue Reading

References

Jun 1, 1997·Biologicals : Journal of the International Association of Biological Standardization·J T Martin
Jan 9, 2003·JAMA : the Journal of the American Medical Association·William W ThompsonKeiji Fukuda
Sep 9, 2004·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Cécile ViboudFabrice Carrat
Aug 19, 2005·American Journal of Epidemiology·John S BrownsteinKenneth D Mandl
Jun 8, 2007·Emerging Infectious Diseases·Caterina RizzoMarta Luisa Ciofi degli Atti
Feb 16, 2008·BMC Public Health·Laura M Glass, Robert J Glass
Jan 7, 2011·Clinical and Vaccine Immunology : CVI·R BodewesG F Rimmelzwaan
Feb 26, 2011·BMC Medical Research Methodology·Jeppe B SchrollPeter C Gøtzsche
May 24, 2011·American Journal of Epidemiology·Dena SchanzerLouise Pelletier
Oct 29, 2011·The Lancet Infectious Diseases·Michael T OsterholmEdward A Belongia
Jan 19, 2012·Human Vaccines & Immunotherapeutics·Christopher S Ambrose, Myron J Levin
Sep 1, 1993·The Canadian Journal of Infectious Diseases = Journal Canadien Des Maladies Infectieuses·C Hannoun
Oct 18, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Paul K S ChanDavid S C Hui
Dec 22, 2012·Expert Review of Vaccines·Derek T O'HaganGiuseppe Del Giudice
Jan 19, 2013·American Journal of Public Health·W Paul GlezenJohn Oxford
Nov 23, 2013·Infection & chemotherapy·Theodore F Tsai
Apr 22, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Su SuAlicia M Fry
Aug 15, 2014·The New England Journal of Medicine·Carlos A DiazGranadosH Keipp Talbot
Aug 21, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Terho HeikkinenThedi Ziegler
Nov 20, 2014·The Journal of Infectious Diseases·Huong Q McLeanEdward A Belongia
Dec 17, 2014·BMC Infectious Diseases·Kavisha JayasundaraAyman Chit
Feb 5, 2015·Epidemiology and Infection·J BeautéUNKNOWN European Influenza Surveillance Network
Mar 31, 2015·PloS One·Eric BudgellCheryl Cohen
Apr 18, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·B ZhaoX Zhang
Jul 30, 2015·American Journal of Epidemiology·Xi-Ling WangChit-Ming Wong
Aug 11, 2015·Influenza and Other Respiratory Viruses·Saverio CainiUNKNOWN Global Influenza B Study
Sep 1, 2015·International Journal of Evidence-based Healthcare·Zachary MunnCatalin Tufanaru
Sep 10, 2015·Infectious Diseases and Therapy·Mark MullikinEckhardt Petri
Dec 15, 2015·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Donald B SmithPeter Simmonds
Feb 19, 2016·Human Vaccines & Immunotherapeutics·Monica TafallaMarije Vonk Noordegraaf-Schouten
Apr 15, 2016·Viruses·Sai Vikram VemulaIndira Hewlett
May 18, 2016·Human Vaccines & Immunotherapeutics·Amos GarcíaRaúl Morano Larragueta
Sep 22, 2016·Influenza and Other Respiratory Viruses·Aye M MoaChandini R MacIntyre
Sep 30, 2016·The New England Journal of Medicine·John J Treanor

❮ Previous
Next ❯

Citations

Feb 9, 2019·Human Vaccines & Immunotherapeutics·Ilaria LopertoMaria Triassi
Apr 1, 2019·European Journal of Public Health·Chiara de WaureRoberto Gasparini
Oct 2, 2019·The American Journal of Tropical Medicine and Hygiene·Fabio TramutoFrancesco Vitale
Jun 20, 2020·Aging Clinical and Experimental Research·Fabio PerrottaAndrea Bianco
Jan 14, 2021·Curēus·Nischit BaralSandip Karki

❮ Previous
Next ❯

Software Mentioned

MetaXL
Embase
Ovid
Stata

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.