Heterogeneous extracellular dopamine regulation in the subregions of the olfactory tubercle

Journal of Neurochemistry
Jinwoo ParkRohan V Bhimani

Abstract

Recent studies show that dense dopamine (DA) innervation from the ventral tegmental area to the olfactory tubercle (OT) may play an important role in processing multisensory information pertaining to arousal and reward, yet little is known about DA regulation in the OT. This is mainly due to the anatomical limitations of conventional methods of determining DA dynamics in small heterogeneous OT subregions located in the ventral most part of the brain. Additionally, there is increasing awareness that anteromedial and anterolateral subregions of the OT have distinct functional roles in natural and psychostimulant drug reinforcement as well as in regulating other types of behavioral responses, such as aversion. Here, we compared extracellular DA regulation (release and clearance) in three subregions (anteromedial, anterolateral, and posterior) of the OT of urethane-anesthetized rats, using in vivo fast-scan cyclic voltammetry following electrical stimulation of ventral tegmental area dopaminergic cell bodies. The neurochemical, anatomical, and pharmacological evidence confirmed that the major electrically evoked catecholamine in the OT was DA across both its anteroposterior and mediolateral extent. While both D2 autoreceptors and D...Continue Reading

References

Jan 1, 1971·Acta Physiologica Scandinavica. Supplementum·U Ungerstedt
Oct 1, 1984·The Journal of Comparative Neurology·O E Millhouse, L Heimer
Sep 29, 1999·Analytical Chemistry·D J MichaelR M Wightman
Jul 17, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Wei-Xing ShiYan Zhou
Aug 4, 2004·Journal of Neurochemistry·Donita L Robinson, R Mark Wightman
May 18, 2005·Alcoholism, Clinical and Experimental Research·Donita L RobinsonR Mark Wightman
Jan 18, 2006·Molecular Therapy : the Journal of the American Society of Gene Therapy·Cassia N Cearley, John H Wolfe
Jan 16, 2007·Analytical Chemistry·B E Kumara Swamy, B Jill Venton
Aug 1, 2007·Journal of Neurochemistry·Justin M KitaR Mark Wightman
Sep 18, 2007·The European Journal of Neuroscience·R Mark WightmanRegina M Carelli
Jun 26, 2008·Chemical Reviews·Donita L RobinsonR Mark Wightman
Feb 13, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Leslie A SombersR Mark Wightman
Nov 10, 2009·Biosensors & Bioelectronics·Matthew K ZachekGregory S McCarty
Feb 2, 2010·Neurochemistry International·Luciano Minuzzi, Paul Cumming
Aug 31, 2010·Neuroscience and Biobehavioral Reviews·Daniel W Wesson, Donald A Wilson
Nov 6, 2012·Brain Research·Yi-Chun Hsieh, Adam C Puche
Feb 9, 2013·Journal of Neuroscience Methods·Caroline E BassEvgeny A Budygin
Nov 26, 2013·Behavioural Brain Research·Carmen Agustín-PavónEnrique Lanuza
Feb 5, 2014·Current Opinion in Neurobiology·Andrew J Giessel, Sandeep Robert Datta
Mar 20, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marie A GadziolaDaniel W Wesson

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Citations

Nov 23, 2019·Journal of Neurochemistry·Hillary L CanslerDaniel W Wesson

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