Heterogeneous mechanics of the mouse pulmonary arterial network

Biomechanics and Modeling in Mechanobiology
Pilhwa LeeDaniel A Beard

Abstract

Individualized modeling and simulation of blood flow mechanics find applications in both animal research and patient care. Individual animal or patient models for blood vessel mechanics are based on combining measured vascular geometry with a fluid structure model coupling formulations describing dynamics of the fluid and mechanics of the wall. For example, one-dimensional fluid flow modeling requires a constitutive law relating vessel cross-sectional deformation to pressure in the lumen. To investigate means of identifying appropriate constitutive relationships, an automated segmentation algorithm was applied to micro-computerized tomography images from a mouse lung obtained at four different static pressures to identify the static pressure-radius relationship for four generations of vessels in the pulmonary arterial network. A shape-fitting function was parameterized for each vessel in the network to characterize the nonlinear and heterogeneous nature of vessel distensibility in the pulmonary arteries. These data on morphometric and mechanical properties were used to simulate pressure and flow velocity propagation in the network using one-dimensional representations of fluid and vessel wall mechanics. Moreover, wave intensity...Continue Reading

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Citations

Jul 4, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Melody DongJeffrey A Feinstein
Jul 30, 2019·International Journal for Numerical Methods in Biomedical Engineering·Mitchel J ColebankMette S Olufsen
Oct 5, 2018·Biomechanics and Modeling in Mechanobiology·M Umar QureshiMette S Olufsen

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