Heterogeneous MHC II restriction pattern of autoreactive desmoglein 3 specific T cell responses in pemphigus vulgaris patients and normals

The Journal of Investigative Dermatology
Michael HertlS I Katz

Abstract

Pemphigus vulgaris is a life threatening bullous autoimmune disease of the skin mediated by autoantibodies against desmoglein 3 (Dsg3) on epidermal keratinocytes. Pemphigus vulgaris patients exhibit T cell responses against Dsg3 that may serve as a target to modulate the production of pathogenic autoantibodies. Healthy carriers of major histocompatibility complex class II alleles identical or similar to those that are highly prevalent in pemphigus vulgaris, namely DRbeta1*0402 and DRbeta1*1401, also mount T cell responses against Dsg3. We thus wanted to determine whether these prevalent major histocompatibility complex class II alleles restricted Dsg3 specific T cell responses. A CD4+ T cell line from the DRbeta1*0402+ patient PV9 was stimulated by Dsg3 with DRbeta1*0402+ L cells as antigen-presenting cells. A CD4+ T cell line and six CD4+ T cell clones from the DR11/14+ patient PV8, and six CD4+ T cell clones from the DR11+ healthy donor C6, required DR11/ DQbeta1*0301+ peripheral blood mononuclear cells but not DR11+ L cells as antigen-presenting cells and were strongly inhibited by anti-DQ antibodies, indicating that they were restricted by HLA-DQbeta1*0301. A CD4+ T cell line and three T cell clones from the DR11+ healthy d...Continue Reading

References

Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A R AhmedE J Yunis
Aug 1, 1991·Human Immunology·H NiizekiT Nishikawa
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A R AhmedC A Alper
Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·F SzaferK Holubar
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S J ScharfH A Erlich
May 1, 1995·The Journal of Experimental Medicine·J HammerF Sinigaglia
Jan 10, 1998·The Journal of Investigative Dermatology·M HertlS I Katz

❮ Previous
Next ❯

Citations

Jun 3, 1999·The British Journal of Dermatology·M J RicoR P Hall
Oct 27, 2006·The New England Journal of Medicine·John R Stanley, Masayuki Amagai
Apr 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·P B RobbinsP A Khavari
Sep 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·W PfutznerJ C Vogel
May 4, 2006·The Journal of Clinical Investigation·Michael HertlChristian Veldman
Nov 26, 2015·Seminars in Immunopathology·Giovanni Di ZenzoLuca Borradori
Nov 23, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Christian VeldmanMichael Hertl
Feb 27, 2009·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Michael Hertl
Apr 1, 2008·Clinical and Experimental Immunology·J N H SternA R Ahmed
May 9, 2012·The British Journal of Dermatology·L YanK Zeng
Sep 24, 2011·Autoimmunity·Sergei A Grando
Oct 24, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·Crispian Scully, Stephen J Challacombe
May 13, 2005·Oral Diseases·M BlackC Scully
Oct 7, 2005·Autoimmunity·Selwyn ChowAnimesh A Sinha
Sep 26, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rüdiger EmingMichael Hertl
Mar 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christian M VeldmanMichael Hertl
Jan 18, 2014·Experimental Dermatology·Kyle T AmberMichael Hertl
Jan 10, 2018·Clinical Reviews in Allergy & Immunology·Robert PollmannMichael Hertl
Dec 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christian VeldmanMichael Hertl
Nov 14, 2001·Clinics in Dermatology·P Martel, P Joly
Jun 24, 1999·Journal of Dermatological Science·M Amagai
May 5, 2005·Journal of Autoimmunity·François TronMourad Ben Ayed
Jul 16, 2021·The Journal of Investigative Dermatology·Christoph HudemannRüdiger Eming

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.