Heterogeneous oncologic outcomes according to surgical pathology in high-risk prostate cancer: implications for better risk stratification and preoperative prediction of oncologic outcomes

Journal of Cancer Research and Clinical Oncology
Seung-Kwon ChoiHanjong Ahn

Abstract

To evaluate the better risk stratification based on surgical pathology, and to predict oncologic outcomes after radical prostatectomy (RP) with a better scoring system in high-risk prostate cancer (PCa) patients. We evaluated high-risk PCa patients (PSA >20 ng/ml, ≥cT3a, or Gleason score 8-10) who underwent RP between 2007 and 2013 at our institute. We classified patients into three groups according to their pathologic outcomes: favorable (pT2, Gleason score ≤7, and node negative), intermediate (specimen-confined disease (pT2-3a, node negative PCa with negative surgical margins) but not in the favorable group), and unfavorable (the remaining patients). We developed a risk stratification scoring system to predict prognostic outcomes after RP and validated our scoring system to estimate its predictive accuracy. Among a total of 356 patients, 95 (26.7%), 115 (32.3%), and 146 (41%) were in the favorable, intermediate, and unfavorable prognostic groups, respectively. The 5-year biochemical recurrence-free survival rates of the patients in each group were 87.8, 64.6, and 41.4%, respectively. We developed a scoring system based on preoperative PSA, clinical stage, percentage of tumor positive core, and percentage of cores with a Gleas...Continue Reading

References

May 30, 1998·Journal of the National Cancer Institute·M W KattanP T Scardino
May 18, 2006·Journal of the National Cancer Institute·Andrew J StephensonMichael W Kattan
May 19, 2007·The Journal of Urology·Ian ThompsonUNKNOWN AUA Prostate Cancer Clinical Guideline Update Panel
May 13, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jennifer R StarkLorelei A Mucci
Nov 11, 2010·BJU International·Ruslan KoretsJames M McKiernan
Nov 17, 2011·BJU International·William T LowranceJames A Eastham
Sep 3, 2013·European Urology·Mark A Preston, Michael L Blute
Nov 6, 2013·Prostate Cancer and Prostatic Diseases·D SundiA E Ross
Nov 12, 2013·European Urology·Axel HeidenreichUNKNOWN European Association of Urology
Feb 4, 2014·European Urology·Steven JoniauUNKNOWN European Multicenter Prostate Cancer Clinical and Translational Research Group (EMPaCT)
May 9, 2014·Journal of the National Comprehensive Cancer Network : JNCCN·James L MohlerUNKNOWN National Comprehensive Cancer Network
May 14, 2014·Nature Reviews. Urology·Christian BachAnthony Koupparis

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