Heterogeneous photoredox flow chemistry for the scalable organosynthesis of fine chemicals.

Nature Communications
Can YangXinchen Wang

Abstract

Large-scale photochemical synthesis of high value chemicals under mild conditions is an ideal method of green chemical production. However, a scalable photocatalytic process has been barely reported due to the costly preparation, low stability of photosensitizers and critical reaction conditions required for classical photocatalysts. Here, we report the merging of flow chemistry with heterogeneous photoredox catalysis for the facile production of high value compounds in a continuous flow reactor with visible light at room temperature in air. In the flow reactor system, polymeric carbon nitrides, which are cheap, sustainable and stable heterogeneous photocatalysts, are immobilized onto glass beads and fibers, demonstrating a highly flexible construction possibility for devices of the photocatalytic materials. As an example of the production of high value chemicals, important chemical structures such as cyclobutanes, which are basic building blocks for many pharmaceutical compounds, like magnosalin, are synthesized in flow with high catalytic efficiency and stability.

References

Jul 1, 2005·Organic Letters·Matthew B Boxer, Hisashi Yamamoto
Jul 5, 2007·Journal of the American Chemical Society·Kazuaki Ishihara, Kazuhiko Nakano
Apr 12, 2008·Journal of Natural Medicines·Valery M Dembitsky
Nov 11, 2008·Nature Materials·Xinchen WangMarkus Antonietti
Aug 1, 2009·Journal of the American Chemical Society·Xiufang ChenXinchen Wang
Jun 10, 2010·Journal of the American Chemical Society·Michael A IschayTehshik P Yoon
Nov 4, 2010·Journal of the American Chemical Society·Fangzheng SuXinchen Wang
Jan 13, 2011·Angewandte Chemie·Fangzheng SuSiegfried Blechert
Sep 24, 2011·Nature Chemistry·Gregory D ScholesRienk van Grondelle
Oct 29, 2011·Journal of the American Chemical Society·Shishi LinTehshik P Yoon
Mar 21, 2012·Angewandte Chemie·Joseph W TuckerCorey R J Stephenson
Sep 18, 2012·Chemical Science·Michael A IschayTehshik P Yoon
Feb 22, 2013·Angewandte Chemie·Yidong HouIb Chorkendorff
Dec 19, 2013·Chemical Science·Michelle Riener, David A Nicewicz
Aug 20, 2014·Journal of the American Chemical Society·David James MartinJunwang Tang
Sep 25, 2014·Chemistry : a European Journal·Magdalena WoźnicaSiegfried Blechert
Aug 19, 2015·The Journal of Physical Chemistry Letters·Barbara Demmig-AdamsWilliam W Adams
Jan 30, 2018·Angewandte Chemie·Bartholomäus PieberKerry Gilmore
Apr 17, 2018·The Journal of Organic Chemistry·Yohei OkadaHidehiro Kamiya
May 19, 2018·Angewandte Chemie·Quan-Quan ZhouWen-Jing Xiao
Aug 2, 2018·Angewandte Chemie·Aleksandr SavateevMarkus Antonietti
May 31, 2019·Journal of the American Chemical Society·Mary Elisabeth DaubTehshik P Yoon

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Citations

Nov 21, 2020·ChemPlusChem·Stefano Mazzanti, Aleksandr Savateev
Mar 27, 2021·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Yohei Okada
May 25, 2021·Journal of the American Chemical Society·Himadri Sekhar SasmalRahul Banerjee
Jun 18, 2021·Beilstein Journal of Organic Chemistry·Guido GambacortaIan R Baxendale
Jun 30, 2021·Water Science and Technology : a Journal of the International Association on Water Pollution Research·Shengnan XuHaijia Su
Oct 26, 2021·Advanced Science·Min ZhouWingkei Ho

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Methods Mentioned

BETA
transmission electron spectroscopy
X-ray
NMR
electron spin resonance

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