PMID: 11313439Apr 21, 2001Paper

Heterogeneous susceptibility of GABA(A) receptor-mediated IPSCs to depolarization-induced suppression of inhibition in rat hippocampus

The Journal of Physiology
L A MartinBradley E Alger

Abstract

Depolarization-induced suppression of inhibition (DSI) in central neurons is mediated by a transient reduction of [gamma]-aminobutyric acid (GABA) release from interneurons. DSI is induced by a retrograde signal emitted from principal cells. We used electrophysiological recordings from CA1 neurons of the rat hippocampal slice to test the hypothesis that only certain classes of interneurons are susceptible to DSI. DSI of action potential-dependent, spontaneous, inhibitory postsynaptic currents (sIPSCs) in hippocampus is facilitated by carbachol (3 microM), which increases the occurrence of large sIPSCs. Besides carbachol, noradrenaline (norepinephrine; 10 microM), or elevated extracellular potassium (8 mM), could abruptly increase the occurrence of large sIPSCs and DSI in many cases. DSI appeared and disappeared concomitantly with the onset and offset of these large sIPSCs. In contrast, application of AP-5 and CNQX often markedly increased baseline sIPSC activity without enhancing DSI. A brief train of extracellular electrical stimulation could trigger the onset of prolonged, repetitive IPSC activity that was susceptible to DSI. The magnitude of DSI of single evoked IPSCs (eIPSCs) in a given pyramidal cell could be altered by ch...Continue Reading

References

May 1, 1992·The Journal of Physiology·T A Pitler, B E Alger
Dec 1, 1989·Journal of Neuroscience Methods·M G BlantonA R Kriegstein
Aug 1, 1981·Journal of Neuroscience Methods·R A Nicoll, B E Alger
Mar 1, 1995·Journal of Neurobiology·J C Poncer, R Miles
Sep 1, 1995·The European Journal of Neuroscience·E H BuhlP Somogyi
Jan 1, 1996·Hippocampus·T F Freund, G Buzsáki
Oct 6, 1997·Journal of Neurophysiology·Y Kawaguchi
Feb 7, 1998·Pflügers Archiv : European journal of physiology·T Ohno-ShosakuC Yamamoto
Sep 21, 2000·The European Journal of Neuroscience·N HájosT F Freund

❮ Previous
Next ❯

Citations

Oct 9, 2002·Neuropharmacology·G Maccaferri, R Dingledine
Jun 17, 2006·Annual Review of Neuroscience·Vivien ChevaleyrePablo E Castillo
Sep 15, 2004·Neuron·Vivien Chevaleyre, Pablo E Castillo
Aug 11, 2007·Neuropharmacology·Miranda A KarsonBradley E Alger
Aug 22, 2012·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Yuliya V Kucherenko, Florian Lang
Aug 12, 2005·Journal of Neurophysiology·Christian G ReichBradley E Alger
Feb 10, 2006·Journal of Neurophysiology·Masako Isokawa, Bradley E Alger
Jan 8, 2009·Physiological Reviews·Masanobu KanoMasahiko Watanabe
Aug 2, 2013·Journal of Neurophysiology·Franck DubrucOlivier Caillard
Jul 5, 2003·Physiological Reviews·Tamas F FreundDaniele Piomelli
Apr 27, 2002·Science·Rachel I Wilson, Roger A Nicoll

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved