The recent identification through molecular cloning techniques of multiple dopamine receptor subtypes has raised interest in the functional interactions between some of the newly described receptors and their classic counterparts. The dopamine D5 (D1B) receptor gene is of particular interest since there is some evidence that its transcriptional tissue distribution is different than that of the D1 and D2 receptor genes, possibly implying a unique role for the receptor that this gene encodes. This study compares the relative anatomical distribution of dopamine D1, D2, and D5 receptor mRNAs in the rat brain using Northern blot analysis. The results demonstrate that the patterns of expression for these three genes are quite different and tissue specific. Although levels of D1 and D2 mRNA are highest in the striatum, levels of D5 mRNA are proportionately much higher in the midbrain, hippocampus and hypothalamus. In addition two D5 mRNA transcripts were detected in the hippocampus, but not in other brain areas. There were tissue-specific differences in the size of D5 mRNA transcripts in human brain tissue as well. These data may suggest a more specialized role for the dopamine D5 receptor within the mammalian brain.
Localization of multiple dopamine receptor subtype mRNAs in human and monkey motor cortex and striatum
Cloning, molecular characterization, and chromosomal assignment of a gene encoding a second D1 dopamine receptor subtype: differential expression pattern in rat brain compared with the D1A receptor
Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine
Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics
Localization of D1 dopamine receptor mRNA in brain supports a role in cognitive, affective, and neuroendocrine aspects of dopaminergic neurotransmission
The distribution and cellular localization of the serotonin 1C receptor mRNA in the rodent brain examined by in situ hybridization histochemistry. Comparison with receptor binding distribution
Localization of the mRNA for the dopamine D2 receptor in the rat brain by in situ hybridization histochemistry
Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs
Sustained enhancement of AMPA receptor- and NMDA receptor-mediated currents induced by dopamine D1/D5 receptor activation in the hippocampus: an essential role of postsynaptic Ca2+
Unilateral frontal cortex ablation producing neglect causes time-dependent changes in striatal glutamate receptors
Scopolamine augments c-fos and zip/268 messenger RNA expression induced by the full D(1) dopamine receptor agonist SKF-82958 in the intact rat striatum
8,9-dihydroxy-1,2,3,11b-tetrahydrochromeno[4,3,2,-de]isoquinoline (dinoxyline), a high affinity and potent agonist at all dopamine receptor isoforms
Microanatomical localization of dopamine receptor protein immunoreactivity in the rat cerebellar cortex
Neurotransmitter systems of the medial prefrontal cortex: potential role in sensitization to psychostimulants
Time-course effects of a single administration of cocaine on receptor binding and subunit mRNAs of GABA(A) receptors
Differential D1 and D2 receptor-mediated effects on immediate early gene induction in a transgenic mouse model of Huntington's disease
Where is my reward and how do I get it? Interaction between the hippocampus and the basal ganglia during spatial learning
Multi-modal regulation of endogenous D1 dopamine receptor expression and function in the CAD catecholaminergic cell line
Activation of D1 dopamine receptors increases surface expression of AMPA receptors and facilitates their synaptic incorporation in cultured hippocampal neurons
A behavioral genetics approach to understanding D1 receptor involvement in phasic dopamine signaling
Layer V neurons bear the majority of mRNAs encoding the five distinct dopamine receptor subtypes in the primate prefrontal cortex
Polymorphisms in Dopaminergic Genes in Schizophrenia and Their Implications in Motor Deficits and Antipsychotic Treatment
D1, not D2, dopamine receptor activation dramatically improves MPTP-induced parkinsonism unresponsive to levodopa.
First identification of dopamine receptors in pikeperch, Sander lucioperca, during the pre-ovulatory period.
Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.