Heterogeneous tissue-specific transcription of dopamine receptor subtype messenger RNA in rat brain

Brain Research. Molecular Brain Research
L G LaurierS R George

Abstract

The recent identification through molecular cloning techniques of multiple dopamine receptor subtypes has raised interest in the functional interactions between some of the newly described receptors and their classic counterparts. The dopamine D5 (D1B) receptor gene is of particular interest since there is some evidence that its transcriptional tissue distribution is different than that of the D1 and D2 receptor genes, possibly implying a unique role for the receptor that this gene encodes. This study compares the relative anatomical distribution of dopamine D1, D2, and D5 receptor mRNAs in the rat brain using Northern blot analysis. The results demonstrate that the patterns of expression for these three genes are quite different and tissue specific. Although levels of D1 and D2 mRNA are highest in the striatum, levels of D5 mRNA are proportionately much higher in the midbrain, hippocampus and hypothalamus. In addition two D5 mRNA transcripts were detected in the hippocampus, but not in other brain areas. There were tissue-specific differences in the size of D5 mRNA transcripts in human brain tissue as well. These data may suggest a more specialized role for the dopamine D5 receptor within the mammalian brain.

References

Jan 11, 1979·Nature·J W Kebabian, D B Calne
Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·M TitelerP Seeman
Oct 1, 1992·Brain Research. Molecular Brain Research·G W HuntleyS C Sealfon
Oct 22, 1992·Neuroscience Letters·J H Meador-WoodruffS J Watson
May 1, 1991·Brain Research. Molecular Brain Research·G MengodJ M Palacios
Feb 11, 1991·Nucleic Acids Research·M WilkinsonS Lindsey
Dec 30, 1991·Gene·T NguyenB F O'Dowd
Mar 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·D M WeinerM R Brann
Oct 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D K GrandyO Civelli
Jan 1, 1991·Progress in Neuro-psychopharmacology & Biological Psychiatry·J H Meador-WoodruffS J Watson
Nov 27, 1991·Biochemical and Biophysical Research Communications·T NguyenB F O'Dowd
May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·R T FremeauM G Caron
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·F J MonsmaD R Sibley
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·G MengodJ M Palacios
Dec 22, 1988·Nature·J R BunzowO Civelli
May 1, 1988·DNA·P E DanielsonJ G Sutcliffe
Mar 1, 1993·Journal of Neurochemistry·B F O'Dowd
Jan 1, 1993·Annual Review of Neuroscience·J A Gingrich, M G Caron

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Citations

Dec 1, 1995·Brain Research. Molecular Brain Research·S L VranaK E Vrana
Mar 28, 1998·Neuropharmacology·U D'SouzaP R Buckland
Jan 12, 1999·Mechanisms of Ageing and Development·P BariliF Amenta
Dec 15, 2000·Progress in Neurobiology·T M Tzschentke
Jul 23, 2005·The Cerebellum·Panagiotis Giompres, Foteini Delis
May 4, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Caroline C Smith, Robert W Greene
Feb 16, 2010·Neuroscience and Biobehavioral Reviews·Shu-Chen LiLars Bäckman
Oct 5, 2010·Molecular and Cellular Neurosciences·Valerie Z WallRichard D Palmiter
Mar 29, 2014·Frontiers in Systems Neuroscience·Aude Retailleau, Thomas Boraud
Jan 21, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Cecilia P KramarM Flavia Barbano
Dec 7, 2020·European Journal of Pharmacology·Richard B MailmanXuemei Huang
Sep 29, 2020·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Jennifer RocheSylvain Milla

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