Heterogenicity of testicular histopathology and tubules as a predictor of successful microdissection testicular sperm extraction in men with nonobstructive azoospermia

Medicine
Yang YuYuan Pan

Abstract

Only a few studies evaluate the presence of spermatozoa intraoperatively. The study aimed to assess whether the heterogenicity of testicular histopathology and seminiferous tubules can predict the outcome of microdissection testicular sperm extraction (micro-TESE) in men with nonobstructive azoospermia (NOA).The study comprised a retrospective analysis of 94 patients with azoospermia who were referred from 2016 to 2017. Under optical magnification, they were classified into 2 groups based on the diameter of tubules intraoperatively, namely homogeneous tubules and heterogeneous tubules. Postoperatively, patients were divided into 2 groups of heterogeneous histopathology and homogeneous histopathology according to the 8 histopathological classification subgroups. The sperm retrieval rate was the main outcome.Testicular spermatozoa were successfully retrieved in 27 men (28%). The sperm retrieval rate in those with heterogeneous histopathology was higher than men with homogeneous histopathology (47% vs 12%; P < .001). The sperm retrieval rate of each histopathological subgroup in men who had the heterogeneous histopathology was higher, compared with the homogeneous histopathology (Sertoli cell only [SCO]: 30% vs 6%; maturation arre...Continue Reading

References

Jul 1, 1989·The Journal of Urology·J P JarowL I Lipshultz
Jul 1, 1982·Forensic Science International : Synergy·G M Willott
Aug 6, 2013·The Journal of Urology·Campbell F BrysonPeter N Schlegel

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Citations

Jul 25, 2019·Basic and Clinical Andrology·Amin BoukerSalima Fourati
Feb 12, 2021·Expert Review of Proteomics·João C RibeiroPedro Oliveira
Apr 3, 2021·The Journal of International Medical Research·Lin QiYing C Su

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Methods Mentioned

BETA
biopsy

Software Mentioned

SPSS

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