Heterogenous response of B cell chronic lymphocytic leukaemia (B-CLL) cells to anti-human IgM antibody (anti-mu) and B cell stimulatory factor 1 (BSF-1)

British Journal of Haematology
M KawanoA Kuramoto

Abstract

B cell chronic lymphocytic leukaemia (B-CLL) cells from seven patients were examined for 3H-TdR uptake with anti-human IgM antibody (anti-mu) and B cell stimulatory factor 1 (BSF-1)/IL-4. B-CLL cells from one patient could proliferate with anti-mu plus BSF-1, but not with BSF-1 alone. B-CLL cells from two patients responded to BSF-1 alone; one could proliferate more by adding anti-mu, but the proliferation of the other cells was inhibited by adding anti-mu. On the other hand, B-CLL cells from the other four patients responded neither to anti-mu nor to anti-mu plus BSF-1. Surface densities of membrane IgM of B-CLL cells were also analysed by fluorescence activated cell sorter (FACS), but there was no correlation between proliferative response (DNA synthesis) of B-CLL cells to anti-mu and densities of surface membrane IgM. These results show that there is a functional heterogeneity of B-CLL cells with regard to proliferative response to anti-mu and BSF-1.

References

Dec 1, 1978·The Journal of Experimental Medicine·S M FuS R Harris
Jan 20, 1973·Lancet·J WybranH H Fudenberg

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Citations

Feb 19, 2002·Cancer Genetics and Cytogenetics·K F Wong, C C So
Apr 12, 2002·Cancer Genetics and Cytogenetics·Lijun ZhangShibo Li
Nov 7, 2002·Cancer Genetics and Cytogenetics·Lijun ZhangShibo Li
Aug 5, 1998·Cancer Genetics and Cytogenetics·E J SinclairF Ross
Mar 8, 2000·Cancer Genetics and Cytogenetics·B J BaumgartnerD L Van Dyke
May 1, 1989·British Journal of Haematology·D BarnettJ T Reilly

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