Heterologous envelope immunogens contribute to AIDS vaccine protection in rhesus monkeys

Journal of Virology
Norman L LetvinGary J Nabel

Abstract

Because a strategy to elicit broadly neutralizing anti-human immunodeficiency virus type 1 (HIV-1) antibodies has not yet been found, the role of an Env immunogen in HIV-1 vaccine candidates remains undefined. We sought to determine whether an HIV-1 Env immunogen genetically disparate from the Env of the challenge virus can contribute to protective immunity. We vaccinated Indian-origin rhesus monkeys with Gag-Pol-Nef immunogens, alone or in combination with Env immunogens that were either matched or mismatched with the challenge virus. These animals were then challenged with a pathogenic simian-human immunodeficiency virus. The vaccine regimen included a plasmid DNA prime and replication-defective adenoviral vector boost. Vaccine regimens that included the matched or mismatched Env immunogens conferred better protection against CD4(+) T-lymphocyte loss than that seen with comparable regimens that did not include Env immunogens. This increment in protective immunity was associated with anamnestic Env-specific cellular immunity that developed in the early days following viral challenge. These data suggest that T-lymphocyte immunity to Env can broaden the protective cellular immune response to HIV despite significant sequence dive...Continue Reading

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References

Aug 19, 1997·Proceedings of the National Academy of Sciences of the United States of America·N L LetvinJ W Shiver
Jan 14, 1998·Nature Medicine·L XuG J Nabel
Nov 13, 1999·Journal of Virology·J M CrawfordD C Montefiori
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Feb 28, 2002·Annual Review of Immunology·Norman L LetvinDavid C Montefiori
Apr 18, 2003·Current Molecular Medicine·John R Mascola

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Citations

Oct 13, 2006·Springer Seminars in Immunopathology·Lindvi GudmundsdotterBritta Wahren
Sep 28, 2013·Archives of Biochemistry and Biophysics·William LehmanStefan Fischer
Jul 25, 2008·Proceedings of the National Academy of Sciences of the United States of America·Sampa SantraNorman L Letvin
Dec 8, 2010·Proceedings of the National Academy of Sciences of the United States of America·Kaimei SongSrinivas S Rao
Jun 1, 2006·The Journal of Experimental Medicine·Joseph J MattapallilMario Roederer
Jul 14, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ann DuerrLawrence Corey
Dec 6, 2007·The Journal of Infectious Diseases·Steven M JonesHeinz Feldmann
Jan 11, 2008·AIDS Research and Human Retroviruses·Lianxing LiuYiming Shao
Mar 12, 2005·Human Gene Therapy·Dan H Barouch, Gary J Nabel
Nov 7, 2006·AIDS·Josef Vlasak, Ruth M Ruprecht
Jan 22, 2005·Annual Review of Medicine·Norman L Letvin

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