Heterologous immunity and homeostatic proliferation as barriers to tolerance

Current Opinion in Immunology
Devon K TaylorLaurence A Turka

Abstract

The different threshold of activation for memory T cells compared to that of naïve T cells makes them resistant to immunomodulation, thus representing a barrier to tolerance. Recently it has been demonstrated that homeostatic proliferation and heterologous immunity represent two naturally occurring and distinct processes that can generate memory T cells. Homeostatic proliferation refers to the process by which, in a lymphodeficient host, normal T cells 'spontaneously' proliferate in response to self-MHC-peptide complexes. Heterologous immunity refers to a process in which a response to one or more infectious agents generates effector/memory T cells with cross-reactive specificities. Recent new studies have defined the importance of these processes in transplantation models and implicated strategies to induce transplantation tolerance.

References

Apr 1, 1994·The Journal of Experimental Medicine·D F Tough, J Sprent
Oct 15, 1993·Science·E PadovanA Lanzavecchia
Apr 1, 1996·The Journal of Experimental Medicine·C ZimmermanH Pircher
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·W C Kieper, S C Jameson
Nov 13, 1999·Science·K Murali-KrishnaR Ahmed
Dec 2, 1999·Nature·A W Goldrath, M J Bevan
Jun 3, 2000·Annual Review of Immunology·A A Freitas, B Rocha
Mar 23, 2001·Nature Immunology·H Veiga-FernandesB Rocha
Aug 22, 2000·The Journal of Experimental Medicine·A W GoldrathM J Bevan
Aug 22, 2000·The Journal of Experimental Medicine·C D Surh, J Sprent
Mar 23, 2001·Nature Immunology·K S SchlunsL Lefrançois
Mar 15, 2001·Nature Immunology·P MarrackJ Kappler
May 5, 2001·Immunity·M Sykes
Dec 12, 2001·Nature Immunology·Marc A GavinAlexander Rudensky
Feb 5, 2002·Microbes and Infection·Charles D Surh, Jonathan Sprent
May 1, 2002·Transplantation·Caner Süsal, Gerhard Opelz
May 2, 2002·Proceedings of the National Academy of Sciences of the United States of America·Geetha ChalasaniFadi G Lakkis
Jun 19, 2002·The Journal of Experimental Medicine·Ananda W GoldrathEric A Butz
Jul 18, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Anna ValujskikhPeter S Heeger
Sep 24, 2002·Nature Immunology·Jennifer L MatsudaMitchell Kronenberg
Jan 16, 2003·Immunology Letters·Jonathan Sprent, Charles D Surh
Jun 5, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Stuart J KnechtleHans W Sollinger
Nov 18, 2003·Immunological Reviews·Andrew B AdamsChristian P Larsen
Dec 3, 2003·Nature Medicine·Zihao WuLaurence A Turka

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Citations

May 9, 2006·Cancer Immunology, Immunotherapy : CII·Thomas B TomasiA Nazmul H Khan
May 26, 2011·Seminars in Immunopathology·Antonella SistiguLaurence Zitvogel
Oct 19, 2005·The Journal of Experimental Medicine·Hongsi JiangYoshinori Fukui
May 6, 2009·The Journal of Experimental Medicine·Daniel Hirschhorn-CymermanAlan N Houghton
Sep 26, 2009·Current Opinion in Organ Transplantation·Andrew J PageAllan D Kirk
Feb 25, 2010·Transplantation·Lara Danziger-IsakovEmilio D Poggio
May 23, 2013·Transplantation·Karin HockStefan G Tullius
May 30, 2013·Transplantation·Jason M AliGavin J Pettigrew
Sep 9, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Stephen P Cobbold
Jun 15, 2011·Immunotherapy·Gilles BenichouGeorges Tocco
Jun 15, 2011·Immunotherapy·Natalia Marek, Piotr Trzonkowski
Jan 26, 2013·Stem Cells Translational Medicine·Andrea Loewendorf, Marie Csete
Jun 5, 2007·Heart Failure Clinics·Richard N Pierson
Sep 12, 2006·The Surgical Clinics of North America·Douglas A Hale
Apr 14, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·L S KeanC P Larsen
Mar 17, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A Valujskikh
May 14, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·L CherkasskyE D Poggio
Jun 12, 2010·Transplant International : Official Journal of the European Society for Organ Transplantation·Junjie XiaZhongquan Qi
Sep 29, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·G FrumentoF E Chen
Jun 19, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A SiepertP Reinke
Apr 1, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K YamauraN Najafian
Feb 24, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Alwi M ShatryRobert B Levy
Sep 1, 2015·Transplant Immunology·Feng WangChang-Xi Wang
Jul 23, 2015·European Journal of Immunology·Karin HockThomas Wekerle
Mar 19, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·B OhJ Kwun
Jan 10, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M K NelsenR G Gill
Sep 1, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Hiroto EgawaKoichi Tanaka
Jul 18, 2009·Current Opinion in Organ Transplantation·Debbie WatsonStephen I Alexander
Dec 24, 2009·Cellular & Molecular Immunology·Yong Zhao, Xianchang Li
Jul 20, 2007·Journal of the American Society of Nephrology : JASN·Anna Valujskikh, Xian Chang Li
Jul 11, 2013·Current Opinion in Organ Transplantation·Xian C LiRafik M Ghobrial
May 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hong ZhengWarren D Shlomchik
Aug 2, 2013·Transplantation·Maria-Luisa AlegreAnita S Chong
Aug 8, 2008·Current Opinion in Organ Transplantation·Anna Valujskikh
Jun 24, 2015·Transplantation·Wenhao ChenXian C Li
Dec 27, 2016·Frontiers in Immunology·Jose MarinoGilles Benichou
Nov 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shlomit Reich-ZeligerYair Reisner
Nov 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tami ZaftSteffen Jung

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