Heterologous neutralizing antibody induction in a simian-human immunodeficiency virus primate model: lack of original antigenic sin

The Journal of Infectious Diseases
R A RasmussenR M Ruprecht

Abstract

According to the principle of original antigenic sin, neutralizing antibodies (NAbs) initially directed against a single virus strain compromise the immune system's ability to subsequently mount adequate responses against antigenically divergent virus strains. In this study, rhesus macaques, after vaccination and breakthrough infection with homologous simian-human immunodeficiency virus (SHIV), developed strong SHIV-IIIB strain-directed NAb responses that were mostly V3 loop specific. After superinfection with heterologous SHIV89.6P, all macaques developed high-titer SHIV89.6P-specific NAbs without significant boosting of SHIV-IIIB-specific NAbs. These results indicate that prior B cell responses against a single immunodeficiency virus strain do not preclude the later development of NAbs against a divergent strain of the same virus.

Citations

Jun 29, 2002·Current Opinion in Immunology·Flavia Ferrantelli, Ruth M Ruprecht
Jul 4, 2008·Retrovirology·Enrico IaccinoGiuseppe Scala
Nov 15, 2011·Current Opinion in Virology·Samir K LakhasheRuth M Ruprecht
Feb 28, 2002·Annual Review of Immunology·Norman L LetvinDavid C Montefiori

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