Heterometallic Ru-Pt metallacycle for two-photon photodynamic therapy

Proceedings of the National Academy of Sciences of the United States of America
Zhixuan ZhouPeter J Stang

Abstract

As an effective and noninvasive treatment of various diseases, photodynamic therapy (PTD) relies on the combination of light, a photosensitizer, and oxygen to generate cytotoxic reactive oxygen species that can damage malignant tissue. Much attention has been paid to covalent modifications of the photosensitizers to improve their photophysical properties and to optimize the pathway of the photosensitizers interacting with cells within the target tissue. Herein we report the design and synthesis of a supramolecular heterometallic Ru-Pt metallacycle via coordination-driven self-assembly. While inheriting the excellent photostability and two-photon absorption characteristics of the Ru(II) polypyridyl precursor, the metallacycle also exhibits red-shifted luminescence to the near-infrared region, a larger two-photon absorption cross-section, and higher singlet oxygen generation efficiency, making it an excellent candidate as a photosensitizer for PTD. Cellular studies reveal that the metallacycle selectively accumulates in mitochondria and nuclei upon internalization. As a result, singlet oxygen generated by photoexcitation of the metallacycle can efficiently trigger cell death via the simultaneous damage to mitochondrial function a...Continue Reading

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Citations

Mar 14, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Qiang-Yu ZhuQing-Fu Sun
May 9, 2019·Advanced Healthcare Materials·Minhuan LanPengfei Wang
Mar 4, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Wei-Wei QinLiang He
Apr 25, 2020·Chemical Communications : Chem Comm·Jiangping LiuHui Chao
Aug 5, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Xue LiuQiang Zhao
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Jan 24, 2019·Proceedings of the National Academy of Sciences of the United States of America·Yue SunPeter J Stang
Sep 25, 2019·Proceedings of the National Academy of Sciences of the United States of America·Zhixuan ZhouPeter J Stang
Aug 12, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Dulal MusibMithun Roy
Nov 7, 2019·Proceedings of the National Academy of Sciences of the United States of America·Sijia GaoZhongwei Niu
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Aug 17, 2019·Journal of the American Chemical Society·Hajar SepehrpourPeter J Stang
Sep 25, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Liping QiaoHui Chao

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