Heterophilic NCAM-mediated cell adhesion to proteoglycans from chick embryonic brain membranes

Experimental Cell Research
S D StormsB A Murray

Abstract

The vertebrate neural cell adhesion molecule NCAM mediates adhesion by both homophilic and heterophilic mechanisms, with heparan sulfate proteoglycans (HSPGs) being likely heterophilic ligands. In this study, transfected chicken NCAM polypeptides expressed on mouse L cells mediated the adhesion of these cells to several different heparan sulfate proteoglycans in nonionic detergent extracts of Embryonic Day 10 chicken brain membranes. In addition, adhesion inhibition experiments suggested a hitherto-undetected role for chondroitin sulfate proteoglycans in the stimulation of NCAM-mediated adhesion to some, but not all, of the HSPG ligands. Our experiments support the view that NCAM is a multivalent adhesive molecule whose function is affected by interactions with extracellular matrix and cell surface molecules.

Citations

Jan 24, 2009·The Journal of Biological Chemistry·Enzo LainHans Rudolf Brenner
Apr 1, 1996·Cell Adhesion and Communication·S D StormsB A Murray
Feb 28, 2009·The American Journal of Pathology·Stefan GattenlöhnerHans-Konrad Müller-Hermelink
Jun 25, 1998·Immunologic Research·F J Kos
Nov 1, 1996·The Journal of Biological Chemistry·C RetzlerU Rauch
Oct 9, 1998·The Journal of Biological Chemistry·S D Storms, U Rutishauser
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