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Heteroplasmic mitochondrial DNA mutations in normal and tumour cells

Nature

Mar 5, 2010

Yiping HeNickolas Papadopoulos

Abstract

The presence of hundreds of copies of mitochondrial DNA (mtDNA) in each human cell poses a challenge for the complete characterization of mtDNA genomes by conventional sequencing technologies. Here we describe digital sequencing of mtDNA genomes with the use of massively parallel sequen...read more

Mentioned in this Paper

Tumor Cells, Uncertain Whether Benign or Malignant
Genome
DNA, Mitochondrial
Tumor Lysis Syndrome
Embryonic Development
Colorectal Neoplasms
Structure of Intestinal Gland
Sequencing
Mitochondria
Genetic Heterogeneity
3
486
1
Paper Details
References
  • References28
  • Citations175
123
  • References28
  • Citations175
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Heteroplasmic mitochondrial DNA mutations in normal and tumour cells

Nature

Mar 5, 2010

Yiping HeNickolas Papadopoulos

PMID: 20200521

DOI: 10.1038/nature08802

Abstract

The presence of hundreds of copies of mitochondrial DNA (mtDNA) in each human cell poses a challenge for the complete characterization of mtDNA genomes by conventional sequencing technologies. Here we describe digital sequencing of mtDNA genomes with the use of massively parallel sequen...read more

Mentioned in this Paper

Tumor Cells, Uncertain Whether Benign or Malignant
Genome
DNA, Mitochondrial
Tumor Lysis Syndrome
Embryonic Development
Colorectal Neoplasms
Structure of Intestinal Gland
Sequencing
Mitochondria
Genetic Heterogeneity
3
486
1

Similar Papers Found In These Feeds

Prenatal Sequencing (Keystone)

Fetal DNA sequencing improves the accuracy of prenatal screening tests for genetic conditions and at times has led to the diagnosis of maternal conditions that may have otherwise gone undetected. Discover the latest research using prenatal sequencing in this feed.

Embryogenesis

Embryogenesis is the process by which the embryo forms and develops. It starts with the fertilization of the egg cell (ovum) by a sperm cell, (spermatozoon). Once fertilized, the ovum is referred to as a zygote, a single diploid cell. The zygote undergoes mitotic divisions with no significant growth (a process known as cleavage) and cellular differentiation, leading to development of a multicellular embryo

Related Papers

American Journal of Human Genetics

Detecting heteroplasmy from high-throughput sequencing of complete human mitochondrial DNA genomes

American Journal of Human GeneticsAugust 11, 2010
Mingkun LiMark Stoneking
Paper Details
References
  • References28
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123
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