Heterosis as a consequence of regulatory incompatibility

BMC Biology
Rebecca H HerbstNaama Barkai

Abstract

The merging of genomes in inter-specific hybrids can result in novel phenotypes, including increased growth rate and biomass yield, a phenomenon known as heterosis. Heterosis is typically viewed as the opposite of hybrid incompatibility. In this view, the superior performance of the hybrid is attributed to heterozygote combinations that compensate for deleterious mutations accumulating in each individual genome, or lead to new, over-dominating interactions with improved performance. Still, only fragmented knowledge is available on genes and processes contributing to heterosis. We describe a budding yeast hybrid that grows faster than both its parents under different environments. Phenotypically, the hybrid progresses more rapidly through cell cycle checkpoints, relieves the repression of respiration in fast growing conditions, does not slow down its growth when presented with ethanol stress, and shows increased signs of DNA damage. A systematic genetic screen identified hundreds of S. cerevisiae alleles whose deletion reduced growth of the hybrid. These growth-affecting alleles were condition-dependent, and differed greatly from alleles that reduced the growth of the S. cerevisiae parent. Our results define a budding yeast hybr...Continue Reading

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Citations

Sep 25, 2019·Genome Research·Samuel M LancasterMaitreya J Dunham
Jul 23, 2020·G3 : Genes - Genomes - Genetics·Eyal Metzl-RazNaama Barkai
Aug 25, 2019·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Jacob D WashburnJames A Birchler
Mar 16, 2021·Frontiers in Genetics·Marlee R LabrooJessica E Rutkoski
Mar 27, 2021·Nature Reviews. Microbiology·Jan SteenselsKevin J Verstrepen
Mar 27, 2021·Evolutionary Applications·Carla BautistaChristian R Landry
Sep 15, 2021·PLoS Genetics·Faisal AlZabenRachel B Brem

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BETA
electron microscopy
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flow cytometry
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PCR

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