Heterosis for viability, fecundity, and male fertility in Drosophila melanogaster: comparison of mutational and standing variation.

Genetics
J D FryTrudy F C Mackay

Abstract

If genetic variation for fitness traits in natural populations ("standing" variation) is maintained by recurrent mutation, then quantitative-genetic properties of standing variation should resemble those of newly arisen mutations. One well-known property of standing variation for fitness traits is inbreeding depression, with its converse of heterosis or hybrid vigor. We measured heterosis for three fitness traits, pre-adult viability, female fecundity, and male fertility, among a set of inbred Drosophilia melanogaster lines recently derived from the wild, and also among a set of lines that had been allowed to accumulate spontaneous mutations for over 200 generations. The inbred lines but not the mutation-accumulation (MA) lines showed heterosis for pre-adult viability. Both sets of lines showed heterosis for female fecundity, but heterosis for male fertility was weak or absent. Crosses among a subset of the MA lines showed that they were strongly differentiated for male fertility, with the differences inherited in autosomal fashion; the absence of heterosis for male fertility among the MA lines was therefore not caused by an absence of mutations affecting this trait. Crosses among the inbred lines also gave some, albeit equivoc...Continue Reading

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Citations

Nov 18, 2011·Biology Letters·Martin A MalletAdam K Chippindale
Dec 22, 2006·PloS One·Claire C MiltonSuzannah Rutherford
Apr 22, 2003·Evolution; International Journal of Organic Evolution·J FernándezA Caballero
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Jul 26, 2003·Nature Genetics·Maria De LucaTrudy F C Mackay
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Mar 12, 2004·Mechanisms of Ageing and Development·Gretchen L Geiger-Thornsberry, Trudy F C Mackay
Apr 17, 2010·Evolution; International Journal of Organic Evolution·Nicola S H TienMartijn Egas

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