Heterostructured Silk-Nanofiber-Reduced Graphene Oxide Composite Scaffold for SH-SY5Y Cell Alignment and Differentiation

ACS Applied Materials & Interfaces
Huaibin QingFeng Xu

Abstract

Stem cell therapy is promising for treating traumatic injuries of the central nervous system, where a major challenge is to effectively differentiate neural stem cells into neurons with uniaxial alignment. Recently, controlling stem cell fate by modulating biophysical cues (e.g., stiffness, conductivity, and patterns) has emerged as an attractive approach. Herein, we report a new heterostructure composite scaffold to induce cell-oriented growth and enhance the neuronal differentiation of SH-SY5Y cells. The scaffold is composed of aligned electrospinning silk nanofibers coated on reduced graphene paper with high conductivity and good biocompatibility. Our experimental results demonstrate that the composite scaffold can effectively induce the oriented growth and enhance neuronal differentiation of SH-SY5Y cells. Our study develops a novel scaffold for enhancing the differentiation of SH-SY5Y cells into neurons, which holds great potential in the treatment of neurological diseases and injuries.

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Citations

Oct 3, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·R ElashnikovO Lyutakov
Feb 25, 2020·Journal of the Mechanical Behavior of Biomedical Materials·Jacek K WychowaniecKrzysztof Tadyszak
Feb 16, 2021·Acta Mechanica Sinica = Li Xue Xue Bao·Xinkai XuLiang Guo
Feb 14, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Amir JafariBehnaz Ashtari
Mar 7, 2021·Nanomaterials·Olga Y AntonovaYuri M Shlyapnikov
May 4, 2020·Advances in Colloid and Interface Science·Sanjay TiwariPratap Bahadur
Jul 10, 2021·Frontiers in Bioengineering and Biotechnology·Dakshi KochharRosalyn D Abbott
Dec 12, 2020·ACS Applied Materials & Interfaces·Antonio Dominguez-AlfaroMaurizio Prato
Mar 3, 2020·ACS Applied Materials & Interfaces·Laura TamayoM D Urzúa
Dec 5, 2019·ACS Applied Materials & Interfaces·Huibin QingFeng Xu
Apr 30, 2020·ACS Applied Materials & Interfaces·Ji Yeon KimCarlos R Baiz
Aug 19, 2020·ACS Applied Materials & Interfaces·André F GirãoPaula A A P Marques
Nov 10, 2020·ACS Applied Materials & Interfaces·Xiaojing WangWei Huang
Sep 28, 2021·Frontiers in Cell and Developmental Biology·Chenyang GuLukui Chen
Dec 10, 2021·Artificial Cells, Nanomedicine, and Biotechnology·Xin-Hong WangTing-Ting Dai

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