Heterosynaptic metaplastic regulation of synaptic efficacy in CA1 pyramidal neurons of rat hippocampus

Hippocampus
D Le RayW Buño

Abstract

The induction threshold, and the magnitude and direction of changes in synaptic plasticity may depend on the previous history of neuronal activity. This phenomenon, termed "metaplasticity," could play an important role in integration processes by coordinating the modulation of synapses. Although metaplasticity has been analyzed extensively, its underlying cellular mechanisms remain largely unknown. Using in vitro electrophysiological and computer simulation approaches, we investigated the contribution of the slow Ca2+-dependent afterhyperpolarization (sAHP) in the metaplastic control of the induction of long-term potentiation (LTP) at convergent CA3-CA1 pyramidal neuron synapses. We report that classical conditioning protocols may lead to the simultaneous induction of a sustained homosynaptic LTP and a potentiation of the sAHP that endured approximately 1 h. The sAHP potentiation dramatically altered the spike responses of the CA1 pyramidal neuron. Of particular interest was the reduction of the CA1 neuron excitability and, consequently, of the capacity of a nonpotentiated synaptic input to elicit spikes while the sAHP was potentiated. This reduction in excitability temporarily prevented nonpotentiated synaptic inputs to exhibi...Continue Reading

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Citations

Apr 11, 2008·Nature Reviews. Neuroscience·Wickliffe C Abraham
Dec 4, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Sarah R HulmeWickliffe C Abraham
May 28, 2009·Learning & Memory·Catherine C Kaczorowski, John F Disterhoft
Sep 4, 2008·Journal of Integrative Neuroscience·Bruce G Mockett, Sarah R Hulme
Sep 18, 2009·Journal of Neurophysiology·Vladislav VolmanTerrence J Sejnowski
Jul 11, 2006·Proceedings of the National Academy of Sciences of the United States of America·Claudia Roth-AlpermannTobias Bonhoeffer
Mar 19, 2009·Neurobiology of Learning and Memory·Rosemary C BagotMarian Joëls
Apr 7, 2015·International Journal of Neural Systems·Pablo MesejoAna B Porto-Pazos
Mar 11, 2015·Developmental Cognitive Neuroscience·Daniel G McHail, Theodore C Dumas
Jun 12, 2013·Neurobiology of Learning and Memory·Owen D JonesWickliffe C Abraham
Jun 12, 2018·The Journal of Physiology·Ying-Zu HuangChin-Song Lu
Aug 27, 2005·Journal of Neurophysiology·Brian D Burrell, Christie L Sahley
Mar 3, 2007·Journal of Neurophysiology·David Fernández de SevillaWashington Buño
Oct 30, 2009·Journal of Neurophysiology·Marco FuenzalidaWashington Buño
Aug 6, 2020·International Journal of Molecular Sciences·Patrizia AmbroginiRiccardo Cuppini

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