Heterotopic bone formation in rectal carcinoma. Case report and literature review

Digestive Diseases and Sciences
M Q AnsariL C Alpert

Abstract

A case of heterotopic bone formation in a primary rectal adenocarcinoma was recently observed in a 54-year-old woman. This unusual finding was present both in the diagnostic biopsy and in the subsequently resected bowel. Pertinent gross and microscopic features are presented. This report represents the twelfth case in the literature of heterotopic bone formation in a primary rectal adenocarcinoma and the first such finding in a colonic biopsy from one of these malignancies. The average age of these patients was 56 years (range 32-72) and the male-to-female ratio was 5:7. The rectum is the most common site of ossification in the gastrointestinal tract. The exact mechanism of heterotopic ossification is unknown, but it is probably the result of metaplasia of fibroblasts. Adenocarcinoma has been associated with 12 of the 16 reported cases of rectal glandular tumors with heterotopic bone.

References

Jun 15, 1976·Zeitschrift Für Krebsforschung Und Klinische Onkologie. Cancer Research and Clinical Oncology·B WernerH Breucker
Mar 5, 1976·Virchows Archiv. A, Pathological Anatomy and Histology·U BettendorfH Laaff
Jan 1, 1989·Human Pathology·J C RandallH C Anderson
Jul 1, 1972·American Journal of Surgery·J W Sampsel, F Callaway
Nov 1, 1968·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·A F Govoni, A N Alcantara
Feb 1, 1984·Annals of the Rheumatic Diseases·L H RosenbaumL D Ellis
Aug 1, 1981·Gastrointestinal Endoscopy·M H Sperling, C J Friedman
Feb 3, 1962·JAMA : the Journal of the American Medical Association·S ENGEL, M B DOCKERTY
Jan 1, 1962·Gastroenterologia·A URBANKE
Apr 1, 1962·The American Journal of Digestive Diseases·M R SHEVACH
Apr 1, 1951·The Journal of Pathology and Bacteriology·A C CHRISTIE
May 15, 1948·British Medical Journal·I JUVARA, U BORCESCU

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Citations

Nov 17, 1998·Journal of the Royal Society of Medicine·M C PapadopoulosA B Ball
Sep 25, 1999·Diseases of the Colon and Rectum·H YoshikawaK Nakanishi
Feb 26, 2003·Der Pathologe·J BirzeleK-M Müller
Oct 17, 2017·Oncotarget·Xibo LiuLirong Chen
May 1, 1995·Pathology International·T NaritaS Yokoyama
Dec 7, 2000·Pathology International·H HaraT Kameya
Dec 23, 2014·Journal of Medical Case Reports·Mauro LiberatoreGiandomenico Miscusi
Jul 1, 1997·Journal of Computer Assisted Tomography·N J BeauchampE K Fishman
Apr 1, 1995·In Vitro Cellular & Developmental Biology. Animal·T NaritaH Kudo
Feb 5, 2000·AJR. American Journal of Roentgenology·K Yonetsu, T Nakamura
Feb 1, 2003·Journal of Surgical Oncology·Alan P KypsonHilliard F Seigler
Nov 24, 2011·European Journal of Gastroenterology & Hepatology·Erik Andrew BowmanBret J Spier
May 16, 2008·International Journal of Surgical Pathology·Kim Billingham, Miroslav Radojkovic
Oct 4, 2005·Archives of Pathology & Laboratory Medicine·Hatim Al-MaghrabiJohn P Veinot
Aug 31, 2007·Pathology, Research and Practice·Katharine LiuLester J Layfield

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