Abstract
This study was undertaken to validate the potential of 31P magnetic resonance spectroscopy (MRS) as a noninvasive alternative for transvenous endomyocardial biopsy in detecting cardiac allograft rejection. Donor hearts from either Lewis rats (L) or Brown-Norway rats (BN) were transplanted into the neck of L rats resulting in a non-rejecting group L-L and a rejecting group L-BN. L-L and L-BN rats were serially studied by means of 31P MRS from postoperatine day 1-8. In addition, rejection was confirmed by histology. A similar, marked decrease in phosphocreative/beta- adenosinetriphosphate (PCr/ATP) ratio from day 1-3 was observed in both L-L and L-BN hearts. This ratio levelled off on postoperative day 3 and remained depressed on subsequent postoperative days in both groups, although histology showed an increase in the severity of rejection in L-BN. However, the PCr signal/noise ratio in L-BN started to decrease after day 4, coinciding with the histologic evidence of severe rejection (score IV), whereas in L-L hearts (score 0) this ratio remained unaltered until day 8. Since high-energy phosphate metabolism is affected by the unloaded status of the heterotopically transplanted heart, irrespective of rejection, the PCr/ATP ratio a...Continue Reading
References
Feb 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A R Mazzeo, G C Levy
Apr 1, 1991·Circulation Research·I KleinC Hong
Jan 1, 1992·Circulation·J D Hosenpud
Aug 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J R GoberG S Karczmar
Oct 1, 1991·Radiology·P A BottomleyW A Baumgartner
Feb 1, 1990·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J R GoberB Massie
Mar 1, 1990·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Y Rozenman, H L Kantor
Apr 1, 1990·Journal of Molecular and Cellular Cardiology·I KleinS S Schreiber
Dec 1, 1989·Transplantation·C D FraserW A Baumgartner
Dec 1, 1989·Cardiovascular Research·B RajagopalanG K Radda
Feb 1, 1989·The Journal of Clinical Investigation·M A PortmanR S Balaban
May 1, 1986·The Journal of Clinical Investigation·I Klein, C Hong
Sep 1, 1987·Journal of Molecular and Cellular Cardiology·I KleinT R Zerbe
Jan 1, 1988·Transplantation·J I ShapiroL Chan
Aug 1, 1987·Transplantation·C E HaugR Weil
Oct 1, 1987·Transplantation·S SuzukiH Amemiya
Feb 29, 1988·Biochemical and Biophysical Research Communications·K M BrindleG K Radda
May 1, 1987·Journal of the American College of Cardiology·R C CanbyG M Pohost
May 1, 1985·Transplantation·J E MillerM M Ziegler
Jun 1, 1974·Transplantation·N L Tilney
Jan 1, 1995·Journal of Molecular and Cellular Cardiology·M GaliñanesD J Hearse
Feb 1, 1993·The Annals of Thoracic Surgery·J S PiroloT B Ferguson
Citations
Feb 11, 2000·NMR in Biomedicine·J O Van DobbenburghC J Van Echteld
May 10, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·T CausM Bernard
Sep 26, 2000·NMR in Biomedicine·N BeckmannM Rudin