PMID: 39128Jun 1, 1979

Heterotopic splenic autotransplantation in prevention of overwhelming postsplenectomy infection

Journal of Pediatric Surgery
D R CooneyR L Telander

Abstract

An experimental study was undertaken to evaluate the protective effect of heterotopic splenic autotransplantation in weanling rats. Rats were divided into three experimental groups: splenectomy, control, and splenic autotransplantation. Rats were challenged with i.v. type I pneumococcus. Bacterial bloodstream clearance and survival were determined. Splenic bacterial uptake was measured by determining the isotopic activity of technetium-99m-labeled pneumococci. Autoradiographs and material stained with hematoxylin and eosin and Gram strains were examined for histologic features. All autografts survived and were histologically compatible with normal splenic tissue. Bloodstream clearance of pneumococci was significantly greater in rats with splenic autotransplantation. Splenic autografts had 10 to 30 times greater uptake of pneumocci than did the liver. Rats with autotransplantation had a prolonged survival time. Heterotopic splenic autotransplantation may prove to be an important adjunctive surgical measure in the treatment of children undergoing splenectomy.

References

Aug 1, 1972·Journal of Pediatric Surgery·A J Eraklis, R M Filler
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Citations

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Related Concepts

Autoradiography
Bacterial Infections
Pneumococcal Infections
Postoperative Complications
Spleen
Splenectomy
Streptococcus pneumoniae
Technetium 99m
Transplantation, Autologous

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