Heterotrimeric G-protein betagamma-dimers in growth and differentiation

Oncogene
William F Schwindinger, Janet D Robishaw

Abstract

Heterotrimeric G-proteins are components of the signal transduction pathways for the soluble and cell-contact signals that regulate normal growth and differentiation. There is now a greater appreciation of the role of the Gbetagamma-dimer in the regulation of a variety of intracellular effectors, including ion channels, adenylyl cyclase, and phospholipase Cbeta. In many cases, Gbetagamma-dimers are required for the activation of mitogen activated protein kinase (MAPK) pathways that promote cellular proliferation, although the underlying mechanisms have yet to be fully elucidated. Activation of phosphotidylinositol-3-kinase (PI3K) is a critical step in the intracellular transduction of survival signals. Gbetagamma-dimers directly activate PI3Kgamma as well as the more widely distributed PI3Kbeta. The activation of PI3Kgamma by Gbetagamma-dimers likely involves direct binding of specific Gbetagamma-dimers to both subunits of PI3Kgamma. Thus, Gbetagamma-dimers transmit signals from numerous receptors to a variety of intracellular effectors in distinct cellular contexts. Five distinct Gbeta-subunits and 12 distinct Ggamma-subunits have been identified. New experimental approaches are needed to elucidate the specific roles of indivi...Continue Reading

References

Jan 1, 1990·Pediatric Radiology·L LauferM Hirsch
Jan 1, 1987·Annual Review of Biochemistry·A G Gilman
Sep 1, 1995·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·P E AustinK A Dunn
Dec 20, 1994·Proceedings of the National Academy of Sciences of the United States of America·W J KochR J Lefkowitz
Dec 15, 1995·Cell·J Downward
Oct 11, 1996·The Journal of Biological Chemistry·C S AbramsS E Rittenhouse
Jan 1, 1997·Gene Therapy·P D GoodD R Engelke
Jan 1, 1997·Annual Review of Pharmacology and Toxicology·D E Clapham, E J Neer
Jan 1, 1997·Annual Review of Biochemistry·W D SingerP C Sternweis
Oct 23, 1997·The Biochemical Journal·I RubioR Wetzker
Feb 19, 1998·The American Journal of Gastroenterology·N B Hershfield
May 26, 1998·Biochemical and Biophysical Research Communications·K ShibataT Akiyoshi
Oct 6, 1998·Annual Review of Biochemistry·D A FrumanL C Cantley
Oct 21, 1998·Oncogene·N DhanasekaranD Onesime
Oct 21, 1998·Oncogene·P F Lebowitz, G C Prendergast
Jan 15, 1999·British Journal of Cancer·M MoriK Sugimachi
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·G IaccarinoW J Koch
Apr 2, 1999·Trends in Pharmacological Sciences·W F Simonds
Apr 21, 1999·Current Opinion in Cell Biology·M A Schwartz, V Baron
Apr 21, 1999·Current Opinion in Cell Biology·L M LuttrellR J Lefkowitz
Apr 21, 1999·Current Opinion in Cell Biology·T P Garrington, G L Johnson
Apr 27, 1999·European Journal of Endocrinology·C M BambergerH M Schulte
May 14, 1999·Trends in Endocrinology and Metabolism : TEM·C MurgaJ S Gutkind
May 29, 1999·The Journal of Biological Chemistry·C S MyungJ C Garrison

❮ Previous
Next ❯

Citations

Sep 29, 2011·Cellular and Molecular Neurobiology·Jia-Ming BianJin Li
Jul 17, 2003·Progress in Biophysics and Molecular Biology·Stefan Offermanns
Mar 8, 2002·Cellular Signalling·Eun Mi Hur, Kyong Tai Kim
Oct 29, 2010·Nature Communications·Juan ZhangQuan Chen
Dec 9, 2008·Nature Medicine·Kristina LorenzMartin J Lohse
May 3, 2005·Nature Reviews. Cancer·Ann M Winter-Vann, Patrick J Casey
Jul 27, 2004·Nature Reviews. Drug Discovery·UNKNOWN Nature Reviews Drug Discovery GPCR Questionnaire Participants
Dec 14, 2012·Proceedings of the National Academy of Sciences of the United States of America·Michelle KwonFrank Park
Feb 24, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kevin R RegnerFrank Park
Aug 4, 2004·Genes & Development·Chih-Hsien ChiuYing-Hue Lee
Jan 22, 2004·Science's STKE : Signal Transduction Knowledge Environment·Yehia Daaka
Oct 7, 2008·Annual Review of Pharmacology and Toxicology·Denis J DupréTerence E Hébert
Mar 21, 2009·Neurological Research·Zhanyang YuXiaoying Wang
Oct 8, 2011·Cell Communication and Signaling : CCS·David R AdamsPatrick A Kiely
May 22, 2010·Journal of the American Society of Nephrology : JASN·Rama NadellaFrank Park
Sep 26, 2002·Journal of Neurosurgery·Stacey A WoodsAbhijit Guha
Jul 28, 2012·International Journal of Molecular Sciences·Zhanyang YuXiaoying Wang
May 2, 2013·Oxidative Medicine and Cellular Longevity·Zhanyang YuXiaoying Wang
Jun 21, 2001·Biochemical and Biophysical Research Communications·J YamauchiG Tsujimoto
Apr 4, 2002·Proceedings of the National Academy of Sciences of the United States of America·Gabriella ColucciMaarten J Chrispeels
Nov 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Adil A KhanDavid A Greenberg
Apr 12, 2006·Proceedings of the National Academy of Sciences of the United States of America·Russell E NichollsPatric K Stanton
Dec 31, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jong-Ik HwangMelvin I Simon
Nov 14, 2006·Proceedings of the National Academy of Sciences of the United States of America·Adil A KhanDavid A Greenberg
Sep 17, 2008·Oncogene·A Carracedo, P P Pandolfi
Dec 24, 2002·The Prostate·Lidia Ruiz-LlorenteInés Díaz-Laviada
Oct 4, 2012·Journal of Dermatological Science·Ichiro YajimaMasashi Kato
Aug 27, 2011·Marine Genomics·Keisuke WakasugiSeiji Watanabe
May 12, 2009·Molecular and Cellular Endocrinology·Adriana R RodriguesAlexandra M Gouveia
Nov 11, 2008·Seminars in Cancer Biology·Joshua B Rubin
Nov 24, 2007·Neuroscience Letters·Kunlin JinDavid A Greenberg

❮ Previous
Next ❯

Related Concepts

Related Feeds

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Related Papers

Biochemical and Biophysical Research Communications
Keisuke WakasugiIsao Morishima
Proceedings of the National Academy of Sciences of the United States of America
Yunjuan SunDavid A Greenberg
© 2021 Meta ULC. All rights reserved