Heterotrimeric G-proteins and development

Biochemical Pharmacology
C C Malbon

Abstract

Heterotrimeric G-proteins are well-known transducers of signaling from a populous class of heptihelical, membrane receptors to a smaller group of effector molecules that includes adenylylcyclases, cyclic GMP phosphodiesterases, phospholipases (type C beta), and various ion channels. Dramatic changes in specific G-protein subunits that coincide with commitment to highly-specialized cell types suggest a key role for these extrinsic membrane proteins in cell differentiation and development. Through analysis of the effects of gain-of-function and loss-of-function mutants, it has been possible to explore this new dimension in G-protein biology, intimately linking specific G-proteins to development. G-protein subunits are shown to be important molecular switches in the complex biological processes controlling both cellular differentiation and early development.

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Citations

Aug 19, 2011·Journal of Agricultural and Food Chemistry·Nien-Chen LinAn-I Yeh
Oct 19, 2005·Nature Reviews. Molecular Cell Biology·Craig C Malbon
Feb 3, 1999·Annals of the New York Academy of Sciences·S EmamiG Rosselin
Jul 26, 2005·Reviews of Physiology, Biochemistry and Pharmacology·M J Cismowski, S M Lanier
Sep 8, 2004·Biochemical and Biophysical Research Communications·Jyotshnabala KanungoCraig C Malbon
Oct 20, 2004·The Journal of Biological Chemistry·Yi-Nan LeeHsien-yu Wang
Nov 9, 2001·The Journal of Biological Chemistry·Hsien-yu WangCraig C Malbon

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