PMID: 8958443Sep 1, 1996Paper

Heterotrimeric G proteins in heart disease

Cellular Signalling
P Schnabel, M Böhm

Abstract

Heterotrimeric G proteins couple many types of cell surface receptors to intracellular effectors such as enzymes or ion channels. In the mammalian heart, G protein-mediated signalling pathways are involved in the regulation of contractile force, heart rate, conduction velocity, and relaxation. In the first part of this review we summarize some important structural and functional features of receptors, G proteins, and effectors with special focus on the heart. In the second part, we review the current knowledge about alterations of G protein-mediated signalling in heart disease such as myocardial hypertrophy and heart failure.

References

Jul 1, 1975·The Journal of Clinical Investigation·W GrossmanL P McLaurin
Sep 18, 1992·Cell·W J Tang, A G Gilman
Jun 15, 1992·European Journal of Biochemistry·M CampsP Gierschik
Aug 1, 1992·Circulation·M Keating
Jan 1, 1991·Annual Review of Biochemistry·H G DohlmanR J Lefkowitz
May 1, 1991·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A M Brown
May 10, 1991·Science·M I SimonN Gautam
Jan 1, 1991·Annual Review of Biochemistry·Y KaziroT Satoh
Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·B N Gao, A G Gilman
Mar 15, 1990·The American Journal of Cardiology·D SiegelS B Hulley
May 7, 1990·Biochimica Et Biophysica Acta·L BirnbaumerA M Brown
Aug 1, 1990·Hypertension·M C MichelP A Insel
Dec 1, 1990·Circulation·S A MorrisJ P Bilezikian
Mar 30, 1990·Biochemical and Biophysical Research Communications·H OhguroT Akino
Apr 1, 1989·Journal of Molecular and Cellular Cardiology·A M FeldmanC Van Dop
Aug 1, 1989·Circulation Research·R von HarsdorfE A Woodcock
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R B ClarkJ A Johnson

❮ Previous
Next ❯

Citations

Mar 14, 2012·Naunyn-Schmiedeberg's Archives of Pharmacology·Kuljeet KaurRichard R Neubig
Oct 14, 2004·Clinical and Experimental Pharmacology & Physiology·Koichiro YasudaKinsuke Tsuda
May 19, 2006·The Tohoku Journal of Experimental Medicine·Yasushi SuwazonoKoji Nogawa
Apr 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·C H RedfernB R Conklin
Apr 16, 2008·European Journal of Pharmacology·Mariëlle C Hendriks-BalkAstrid E Alewijnse
Mar 14, 1998·Circulation·K PönickeO E Brodde
Feb 10, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ulrike MühlhäuserThomas Eschenhagen
Mar 15, 2001·American Journal of Physiology. Heart and Circulatory Physiology·A J BakerB R Conklin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.