PMID: 38925Aug 1, 1979

Heterozygote advantage in cystic fibrosis: mosquito tests

Clinical Genetics
M Super, D J van Schalkwyk


Tests to demonstrate a preference by mosquitoes for stinging controls as opposed to obligate heterozygotes for Cystic Fibrosis proved negative. If a heterozygote advantage caused a lower malarial incidence in carriers in South West Africa, it must have worked through the malarial parasite being adversely affected by a serum factor. This remains to be tested.


May 1, 1977·Archives of Disease in Childhood·J H Edwards
Sep 1, 1974·Journal of Medical Genetics·F L Cohen, W L Daniel
May 1, 1967·Pediatric Research·A SpockW S Logan

Related Concepts

Pulmonary Cystic Fibrosis
Genetic Carriers
Insect Sting

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