Hexachlorobenzene-induced immunomodulation and skin and lung lesions: a comparison between brown Norway, Lewis, and Wistar rats

Toxicology and Applied Pharmacology
C MichielsenJ G Vos

Abstract

Strain dependence of the induction of skin and lung lesions by hexachlorobenzene (HCB) in the rat was studied to further the insight into the etiology of the lesions. To this end, 3- to 4-week-old female Brown Norway (BN), Lewis, and Wistar rats received diets supplemented with 150 mg (BN and Lewis), 450 mg (BN, Lewis, and Wistar) or 900 mg (BN and Wistar) HCB per kilogram diet for 4 weeks. Gross skin lesion development during exposure as well as pathologic changes in skin and lungs and various parameters of immunomodulation after exposure were assessed. General toxicity as judged by a slight increase in body weight gain and induction of liver cell hypertrophy was similar in BN and Lewis rats exposed to 450 mg/kg HCB and in Wistar rats exposed to 900 mg/kg HCB. Skin lesions ranged from redness to large exudating sores with crusts. With regard to dose, time of onset, incidence, and severity, skin lesions were very severe in BN, moderate in Lewis, and negligible in Wistar. Porphyrins could not be detected in the skin, whereas porphyrins in the liver were seen only in Lewis rats. Histology showed epidermal hyperplasia, deep dermal venules with activated endothelium, and deep dermal inflammatory infiltrates mainly consisting of eos...Continue Reading

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Citations

Sep 30, 1999·Environmental Health Perspectives·C C MichielsenJ G Vos
May 26, 2004·Environmental Health Perspectives·Janine EzendamJoseph G Vos
Dec 17, 2011·Autoimmunity Reviews·Cecilia Chighizola, Pier Luigi Meroni
Nov 8, 2005·Toxicology and Applied Pharmacology·Janine EzendamRaymond Pieters
Dec 3, 1999·Toxicology and Applied Pharmacology·C C MichielsenJ E van Dijk
Jun 22, 2000·Toxicologic Pathology·C F KuperJ G Vos
Apr 20, 1999·Toxicologic Pathology·M C BruderC F Kuper
Oct 30, 2008·Journal of Immunotoxicology·Janine EzendamRaymond Pieters
Sep 7, 2019·Journal of Translational Medicine·Birte WeberMiriam Kalbitz
Nov 13, 2017·Pharmacological Reports : PR·Beata Starek-ŚwiechowiczAndrzej Starek
Jun 17, 2003·Chemical Research in Toxicology·Janine EzendamRaymond Pieters
Jun 8, 2002·Toxicology Letters·Michael P Holsapple

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