Hexadentate 3-hydroxypyridin-4-ones with high iron(III) affinity: design, synthesis and inhibition on methicillin resistant Staphylococcus aureus and Pseudomonas strains

European Journal of Medicinal Chemistry
Ying-Jun ZhouTao Zhou

Abstract

A range of hexadentate 3-hydroxypyridin-4-ones have been synthesized. These compounds were found to possess a high affinity for iron(III), with logK1 values of about 34 and pFe values over 30. Antimicrobial assays indicated that they can inhibit the growth of three clinical isolates of methicillin resistant Staphylococcus aureus (MRSA) and three clinical isolates of Pseudomonas, suggesting that hexadentate 3-hydroxypyridin-4-ones have potential application in the treatment of wound infections.

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Citations

Jan 12, 2017·International Journal of Molecular Sciences·Ruslan CusnirMichelle T Ma
Jun 20, 2018·Dalton Transactions : an International Journal of Inorganic Chemistry·Xiaomei WangShuao Wang
Feb 23, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Tao ZhouRobert C Hider
Apr 5, 2020·International Journal of Molecular Sciences·Marialaura MarchettiLuca Ronda
Aug 17, 2019·Journal of Enzyme Inhibition and Medicinal Chemistry·Zhisheng MiYuanyuan Xie
Oct 20, 2020·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Roger Gumbau-BrisaMatthias Bierenstiel
Apr 4, 2021·International Journal of Molecular Sciences·Víctor Vinuesa, Michael J McConnell
May 24, 2021·European Journal of Medicinal Chemistry·Min HeGuangcheng Wang
Jun 10, 2021·ACS Chemical Biology·Usama AbbasiJayachandran N Kizhakkedathu
Oct 8, 2020·Journal of Medicinal Chemistry·Xiaoying JiangYuanyuan Xie
Jul 24, 2018·Chemical Reviews·Agostino CilibrizziRobert C Hider

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