Apr 23, 1982

Hexamethylmelamine and hexamethylmelamine hydrochloride

Pharmaceutisch Weekblad. Scientific Edition
H P van de Vaart-van ZutphenA Hulshoff

Abstract

Methods of analysis of the anticancer drug hexamethylmelamine, its physicochemical properties, its therapeutic uses and its fate in vivo upon oral administration, are described. The data are taken in part from the literature, in part from our own studies. The low solubility of hexamethylmelamine in water has prevented the parenteral administration of the drug to humans. The preparation of the water-soluble monohydrochloride of hexamethylmelamine, which may be suitable for this purpose, is reported, as well as its physicochemical characteristics and methods of analysis.

  • References11
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References

  • References11
  • Citations2

Citations

Mentioned in this Paper

Parenteral Route of Drug Administration
Soluble
Physicochemical Phenomena
Benzotriazines
Hydrochloride
Altretamine
Therapeutic Uses
Hexinawas

About this Paper

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