Hexane extract of Raphanus sativus L. roots inhibits cell proliferation and induces apoptosis in human cancer cells by modulating genes related to apoptotic pathway.

Plant Foods for Human Nutrition
Syed Sultan BeeviJyotheeswara Reddy Edula

Abstract

Raphanus sativus, a common cruciferous vegetable has been attributed to possess a number of pharmacological and therapeutic properties. It has been used in indigenous system of medicine for the treatment of various human ailments in India. This present study evaluated the chemopreventive efficacy of different parts of R. sativus such as root, stem and leaves, extracted with solvents of varying polarity and investigated the molecular mechanism leading to growth arrest and apoptotic cell death in human cancer cell lines. Of the different parts, significant growth inhibitory effect was observed with hexane extract of R. sativus root. Analysis of hexane extract by GC-MS revealed the presence of several isothiocyanates (ITCs) such as 4-(methylthio)-3-butenyl isothiocyanate (MTBITC), 4-(methylthio)-3-butyl isothiocyanate (erucin), 4-methylpentyl isothiocyanate, 4-pentenyl isothiocyanate and sulforaphene. R. sativus root extract induced cell death both in p53 proficient and p53 deficient cell lines through induction of apoptotic signaling pathway regardless of the p53 status of cells. The molecular mechanisms underlying R. sativus-induced apoptosis may involve interactions among Bcl(2) family genes, as evidenced by up-regulation of pr...Continue Reading

References

Feb 24, 1995·Cell·E M MiyashitaD A Thorley-Lawson
Aug 15, 1995·Proceedings of the National Academy of Sciences of the United States of America·T W SedlakS J Korsmeyer
Sep 1, 1993·Carcinogenesis·M A Morse, G D Stoner
Feb 8, 1996·Nature·E H ChengJ M Hardwick
Apr 14, 1999·Cell Death and Differentiation·A G Porter, R U Jänicke
Oct 23, 2003·Nature Reviews. Cancer·Young-Joon Surh
May 6, 2004·Journal of the National Cancer Institute·Shi-Yong SunReuben Lotan
Jun 20, 2007·Plant Foods for Human Nutrition·Bo-Bae LeeSeung-Cheol Lee
Jan 15, 2008·Journal of Agricultural and Food Chemistry·Alessio PapiLuca Valgimigli
Jul 31, 2008·Journal of Agricultural and Food Chemistry·Jessica BarillariLuca Valgimigli
Dec 17, 2008·Plant Foods for Human Nutrition·Siwapong TansuwanwongUsanee Vinitketkumnuen
Jan 15, 2010·Plant Foods for Human Nutrition·Syed Sultan BeeviBandi Boje Gowda

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Citations

Feb 1, 2011·Journal of Experimental Botany·Imène HichriVirginie Lauvergeat
Sep 25, 2012·Plant Foods for Human Nutrition·María Elena CarteaPablo Velasco
Jan 19, 2016·Food Chemistry·Guifang TianJing Hu
Jul 16, 2015·Preventive Nutrition and Food Science·Jae-Won KimSang-Bin Lim
Jan 13, 2015·Journal of Agricultural and Food Chemistry·Hae Won JangTakayuki Shibamoto
May 22, 2013·Journal of Agricultural and Food Chemistry·Dan SongQipeng Yuan
Mar 28, 2017·Journal of Biochemical and Molecular Toxicology·Kewei RenXinwei Han
Nov 30, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Muhammad Din IbrahimAhmad Faizal Abdull Razis
Dec 5, 2020·Journal of the Science of Food and Agriculture·Vijitra Luang-InTeeraporn Katisart

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