Hexapeptides from human milk prevent the induction of oxidative stress from parenteral nutrition in the newborn guinea pig.

Pediatric Research
Khalil MiloudiJean-Claude Lavoie

Abstract

In preterm neonates, peroxides contaminating total parenteral nutrition (TPN) contribute to oxidative stress, which is suspected to be a strong inducer of hepatic complications related to prematurity. Recently, others reported that hexapeptides derived from human milk (HM) exerted free radical-scavenging activities in vitro. Therefore, the aim of this study was to assess the capacity of these hexapeptides to limit the generation of peroxides in TPN and to prevent TPN-induced hepatic oxidative stress. At 3 d of life, guinea pigs were infused, through a catheter in jugular vein, with TPN containing or not peptide-A (YGYTGA) or peptide-B (ISELGW). Peroxide concentrations were measured in TPN solutions, whereas glutathione, glutathionyl-1,4-dihydroxynonenal (GS-HNE) and mRNA levels of interleukin-1 (IL-1) and tumor necrosis factor-α (TNFα) were determined in liver after 4 d of infusion. The addition of peptide-A to TPN allowed a reduction in peroxide contamination by half. In vivo, peptide-A or peptide-B corrected the hepatic oxidative status induced by TPN. Indeed, both peptides lowered the hepatic redox potential of glutathione and the level of GS-HNE, a marker of lipid peroxidation. As compared with animals infused with TPN with...Continue Reading

References

Jan 1, 1991·Pediatric Research·O PitkänenS Andersson
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·K UchidaE R Stadtman
Jan 1, 1997·Free Radical Biology & Medicine·J C Lavoie, P Chessex
Dec 31, 1998·Free Radical Biology & Medicine·M GuichardantM Lagarde
Jan 21, 2000·Free Radical Biology & Medicine·M J DaviesR T Dean
Oct 21, 2000·American Journal of Perinatology·D W Thibeault
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Dec 21, 2002·Critical Care : the Official Journal of the Critical Care Forum·Barry WeinbergerThomas Hegyi
Mar 7, 2003·Pediatric Research·Hiromichi ShojiYuichiro Yamashiro
Jul 2, 2005·Journal of Pediatric Gastroenterology and Nutrition·Jean-Claude LavoieThérèse Rouleau
Oct 6, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Markus G DonnerDieter Häussinger
Aug 12, 2008·The American Journal of Clinical Nutrition·Frans W J Te BraakeJohannes B van Goudoever
Dec 6, 2008·The American Journal of Clinical Nutrition·Ana LedoMaximo Vento
Jun 9, 2009·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·D S FagundesM D Murillo
Sep 5, 2009·Pediatric Research·Apollinaire TsopmoJames K Friel
Jan 22, 2010·Ecotoxicology and Environmental Safety·Hichem SebaiMossadok Ben-Attia
Aug 10, 2010·Free Radical Biology & Medicine·Philippe ChessexJean-Claude Lavoie
Sep 3, 2010·Journal of Perinatal Medicine·Ola Didrik Saugstad
Dec 15, 2010·Current Opinion in Pediatrics·Jennifer W Lee, Jonathan M Davis
Feb 15, 2011·Drug and Chemical Toxicology·Hichem SebaiNéziha Ghanem-Boughanmi

❮ Previous
Next ❯

Citations

Feb 16, 2013·Pediatric Research·Sabrina YaraJean-Claude Lavoie
Jan 15, 2014·The Journal of Nutritional Biochemistry·Yasuaki Wada, Bo Lönnerdal
Dec 3, 2016·Bulletin of Experimental Biology and Medicine·O G PinaevaS S Timoshin
Sep 18, 2015·JPEN. Journal of Parenteral and Enteral Nutrition·Philippe ChessexJean-Claude Lavoie
Apr 11, 2012·Journal of Pediatric Gastroenterology and Nutrition·Amélie StritzkePhilippe Chessex

❮ Previous
Next ❯

Methods Mentioned

BETA
electrophoresis
PCR

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.