Hexavalent chromium induced oxidative stress and apoptosis in Pycnoporus sanguineus

Environmental Pollution
Mi FengZhi Dang

Abstract

White rot fungi have been proved to be a promising option for the removal of heavy metals, understanding their toxic response to heavy metals is conducive to developing and popularizing fungi-based remediation technologies so as to lessen the hazard of heavy metals. In this study, Cr(VI)-induced oxidative stress and apoptosis in Pycnoporus sanguineus, a species of white rot fungi were investigated. The results suggested that high level of Cr(VI) promoted the formation of ROS, including H2O2, O2(•-) and ·OH. With the increment of Cr(VI) concentration, the SOD and CAT activity along with GSH content increased within the first 24 h, but decreased afterward, companied with a significant enhancement of MDA content. Cr(VI)-induced oxidative damage further caused and aggravated apoptosis in P. sanguineus, especially at Cr(VI) concentrations above 20 mg/L. Cr(VI)-induced apoptosis was involved with mitochondrial dysfunction including mitochondrial depolarization, the enhancement of mitochondrial permeability and release of cytochrome c. The early and late apoptosis hallmarks, such as metacaspase activation, phosphatidylserine (PS) externalization, DNA fragmentation and the nuclear condensation and fragmentation were observed. Moreover,...Continue Reading

Citations

Jul 31, 2020·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Shruti Shah, Samir Damare
Apr 5, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ashim SikdarXiuqing Wang
Jun 27, 2019·Metallomics : Integrated Biometal Science·Shruti Shah, Samir Damare
Mar 25, 2021·Environmental Toxicology and Pharmacology·Yiran ZhuJianzhu Liu
Aug 24, 2020·Ecotoxicology and Environmental Safety·Jiashu LiuXiaoyu Zhang

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