Abstract
White rot fungi have been proved to be a promising option for the removal of heavy metals, understanding their toxic response to heavy metals is conducive to developing and popularizing fungi-based remediation technologies so as to lessen the hazard of heavy metals. In this study, Cr(VI)-induced oxidative stress and apoptosis in Pycnoporus sanguineus, a species of white rot fungi were investigated. The results suggested that high level of Cr(VI) promoted the formation of ROS, including H2O2, O2(•-) and ·OH. With the increment of Cr(VI) concentration, the SOD and CAT activity along with GSH content increased within the first 24 h, but decreased afterward, companied with a significant enhancement of MDA content. Cr(VI)-induced oxidative damage further caused and aggravated apoptosis in P. sanguineus, especially at Cr(VI) concentrations above 20 mg/L. Cr(VI)-induced apoptosis was involved with mitochondrial dysfunction including mitochondrial depolarization, the enhancement of mitochondrial permeability and release of cytochrome c. The early and late apoptosis hallmarks, such as metacaspase activation, phosphatidylserine (PS) externalization, DNA fragmentation and the nuclear condensation and fragmentation were observed. Moreover,...Continue Reading
Citations
Jul 31, 2020·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Shruti Shah, Samir Damare
Nov 2, 2019·Environmental Toxicology·Yu GanJiaxiang Chen
Apr 5, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ashim SikdarXiuqing Wang
Nov 23, 2017·Andrologia·O A AdebayoO A Adaramoye
Jun 27, 2019·Metallomics : Integrated Biometal Science·Shruti Shah, Samir Damare
Dec 30, 2020·Journal of Toxicology and Environmental Health. Part a·María Del Carmen García-RodríguezMario Altamirano-Lozano
Oct 23, 2020·Water Research·Hangbo XuZhen Jiao
Sep 29, 2019·Chemosphere·Mi FengJiahua Zhou
Dec 19, 2020·Environmental Pollution·Tong LiuXiuguo Wang
Nov 16, 2020·Chemosphere·Anastasis ChristouVasileios Fotopoulos
Nov 1, 2020·Chemosphere·Liang HuZhiguo He
Feb 22, 2021·Fish Physiology and Biochemistry·Abhay Kumar GiriGyanaranjan Dash
Mar 25, 2021·Environmental Toxicology and Pharmacology·Yiran ZhuJianzhu Liu
Nov 13, 2018·Chemico-biological Interactions·Hong GeJun Cao
May 9, 2021·The Science of the Total Environment·Yutian HuChuanping Feng
Aug 24, 2020·Ecotoxicology and Environmental Safety·Jiashu LiuXiaoyu Zhang
Aug 25, 2020·Ecotoxicology and Environmental Safety·Ying ZhangLilong Yan
Jul 31, 2021·Environment International·Li ShiJianlin Lou
Aug 3, 2021·Ecotoxicology and Environmental Safety·Min NieXiaohu Zhao
Aug 1, 2020·Chemosphere·Teng LiuYang Shen