Hexokinase and phosphofructokinase activity and intracellular distribution correlate with aggressiveness and invasiveness of human breast carcinoma

Oncotarget
Raquel G CoelhoMauro Sola-Penna

Abstract

Glycolytic enzymes, such as hexokinase and phosphofructokinase, have been reported to be upregulated in many cancer types. Here, we evaluated these two enzymes in 54 breast cancer samples collected from volunteers subjected to mastectomy, and the results were correlated with the prognosis markers commonly used. We found that both enzymes positively correlate with the major markers for invasiveness and aggressiveness. For invasiveness, the enzymes activities increase in parallel to the tumor size. Moreover, we found augmented activities for both enzymes when the samples were extirpated from patients presenting lymph node involvement or occurrence of metastasis. For aggressiveness, we stained the samples for the estrogen and progesterone receptors, HER-2, p53 and Ki-67. The enzyme activities positively correlated with all markers but Ki-67. Finally, we conclude that these enzymes are good markers for breast cancer prognosis.

References

Sep 20, 2006·Cancer Research·Jung-whan Kim, Chi V Dang
Jul 1, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Robert J GilliesRobert A Gatenby
Aug 2, 2008·Neoplasia : an International Journal for Oncology Research·Ian F RobeyRobert J Gillies
Sep 9, 2008·Cell·Peggy P Hsu, David M Sabatini
Mar 3, 2009·Biochimica Et Biophysica Acta·Monica M Marinho-CarvalhoMauro Sola-Penna
May 23, 2009·Science·Matthew G Vander HeidenCraig B Thompson
Feb 2, 2010·The Breast : Official Journal of the European Society of Mastology·L M BacchiF M Carvalho
Nov 30, 2010·Biochimica Et Biophysica Acta·Alvaro Marín-HernándezEmma Saavedra
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Mar 11, 2011·The Journal of Biological Chemistry·Juliana GrechiMauro Sola-Penna
May 3, 2011·Molecular Genetics and Metabolism·Raquel Guimarães CoelhoMauro Sola-Penna
May 24, 2011·Cancer Investigation·Dhafir Al-azawiLeonie Young
Nov 1, 2011·The International Journal of Biochemistry & Cell Biology·Wagner Santos CoelhoMauro Sola-Penna
Nov 30, 2011·Current Opinion in Oncology·Jean-Pierre Bayley, Peter Devilee
Sep 27, 2012·Molecular and Cellular Biochemistry·Wagner Santos Coelho, Mauro Sola-Penna
Jul 22, 2014·Cancer·Vandana G AbramsonJennifer A Pietenpol
Dec 3, 2014·Cancer Treatment Reviews·Michael J DuffyWilliam M Gallagher
Mar 10, 2015·Critical Reviews in Oncology/hematology·G MustacchiL Scaltriti
Apr 5, 2015·The Breast : Official Journal of the European Society of Mastology·Angelo Di LeoMartine Piccart
Apr 22, 2015·Nature Reviews. Clinical Oncology·Dimitrios ZardavasMartine Piccart
May 12, 2015·Breast Care·Christoph Engel, Christine Fischer
May 20, 2015·International Journal of Molecular Sciences·Calvin R JustusLi V Yang

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Citations

Apr 10, 2018·Frontiers in Oncology·Raquel Guimaraes CoelhoDenise P Carvalho
Oct 30, 2016·Journal of Cellular Biochemistry·Thyago Rubens Cardim PiresPatricia Zancan
Feb 10, 2017·Cell Death Discovery·Xiaopeng XiongTianyan Gao
Sep 17, 2019·Molecular Medicine Reports·Chaojian LiuHaomiao Li
Oct 30, 2016·Current Opinion in Oncology·Maria Shoshan
Feb 15, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Laura TorresanoJosé M Cuezva
May 29, 2021·Molecular Biology Reports·J R Dev ArundhathiChandra Prakash Prasad

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