HFE C282Y homozygotes are at increased risk of breast and colorectal cancer.

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Nicholas J OsborneDallas R English

Abstract

The evidence that mutations in the HFE gene for hemochromatosis are associated with increased cancer risk is inconsistent. The Melbourne Collaborative Cohort Study is a prospective cohort study that commenced recruitment in 1990. Participants born in Australia, New Zealand, the United Kingdom, or Ireland (n = 28,509) were genotyped for the HFE C282Y (substitution of tyrosine for cysteine at amino acid 282) variant. Incident cancers were ascertained from Australian cancer registries during an average of 14 years follow-up. Hazard ratios (HRs), confidence intervals (CIs), and P values were obtained from separate Cox regression analyses for colorectal, breast, and prostate cancers, all other solid cancers, and all cancers. Compared to those with no C282Y variant, C282Y homozygotes were at increased risk of colorectal cancer (HR = 2.28; 95% CI = 1.22, 4.25; P = 0.01) and female C282Y homozygotes were at increased risk of developing breast cancer (HR = 2.39; 95% CI = 1.24, 4.61; P = 0.01), but male C282Y homozygotes were not at increased risk for prostate cancer (HR = 0.96; 95% CI = 0.43, 2.15; P = 0.92). C282Y/H63D compound heterozygotes were not at increased risk for colorectal cancer (HR = 1.27; 95% CI = 0.80, 2.01), breast cance...Continue Reading

References

Jan 1, 1992·Cytogenetics and Cell Genetics·T MotokuraA Arnold
Jul 1, 1990·Environmental Health Perspectives·R G Stevens, D R Kalkwarf
Apr 1, 1986·Journal of the National Cancer Institute·R G StevensB S Blumberg
Oct 20, 1988·The New England Journal of Medicine·R G StevensP R Taylor
May 15, 1988·International Journal of Cancer. Journal International Du Cancer·J V Selby, G D Friedman
Aug 1, 1988·British Journal of Industrial Medicine
Feb 1, 1994·International Journal of Cancer. Journal International Du Cancer·R G StevensB S Blumberg
Feb 1, 1994·International Journal of Cancer. Journal International Du Cancer·P KnektT Hakulinen
May 18, 1996·Lancet·S FranceschiA Giacosa
Feb 27, 1999·International Journal of Cancer. Journal International Du Cancer·I KatoE Riboli
Mar 18, 1999·Immunogenetics·D A Rhodes, J Trowsdale
Jan 14, 2000·Journal of Gastroenterology and Hepatology·G A MacdonaldB A Leggett
Feb 8, 2000·Blood Cells, Molecules & Diseases·O RacchiA M Ferraris
Aug 23, 2000·Genetic Testing·J J PointonK J Robson
Jan 17, 2003·Journal of the National Cancer Institute·Nicholas J ShaheenRobert S Sandler
Jun 5, 2003·Journal of the National Cancer Institute·Jerome L Sullivan
Sep 2, 2003·Cancer Causes & Control : CCC·Daphne L van der APetra H M Peeters
Sep 16, 2003·Blood Cells, Molecules & Diseases·Gérard Lucotte, Florent Dieterlen
Feb 18, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·K TamakoshiUNKNOWN JACC Study Group
Feb 19, 2004·Cancer Causes & Control : CCC·Allison M HodgeGraham G Giles
Mar 24, 2004·Annals of Epidemiology·Tiejian WuEllen Smit
Apr 21, 2005·Blood·Sérgio F de AlmeidaMaria de Sousa
May 17, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Benny K AbrahamUNKNOWN GENICA Network
Jun 9, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·James P RobinsonAndrew R J Silver
Jun 16, 2005·Journal of the National Cancer Institute·Andrew T ChanCharles S Fuchs
Oct 12, 2005·Biochimica Et Biophysica Acta·Tatiana V KondrashovaAnatoly F Tsyb
Oct 28, 2005·The Journal of Nutrition·Serge HercbergPilar Galan
Jan 21, 2006·International Journal of Cancer. Journal International Du Cancer·Amanda J CrossRashmi Sinha
Jun 23, 2006·Journal of Clinical Pathology·Gda C SantosJ A Squire
Aug 31, 2007·World Journal of Gastroenterology : WJG·Graça Porto, Maria De Sousa
Dec 7, 2007·Lancet·Paul C Adams, James C Barton
Jan 18, 2008·The New England Journal of Medicine·Katrina J AllenDorota M Gertig
May 24, 2008·The New England Journal of Medicine·Jill Waalen, Ernest Beutler
Jul 10, 2008·Journal of the National Cancer Institute·Leo R ZacharskiPhilip W Lavori
Aug 30, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·John K OlynykBruce R Bacon
Oct 14, 2008·Gastroenterology·Lyle C GurrinUNKNOWN HealthIron Study Investigators
Jun 26, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lyle C GurrinUNKNOWN HealthIron Study Investigators

❮ Previous
Next ❯

Citations

Sep 3, 2013·Cancer Causes & Control : CCC·Gabriella M AnicKathleen M Egan
Apr 29, 2010·Current Gastroenterology Reports·Eng K GanJohn K Olynyk
Oct 25, 2011·Hepatology International·Julia O'Brien, Lawrie W Powell
Apr 5, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Weidong ChenHongliang Yao
Apr 19, 2013·Nature Reviews. Cancer·Suzy V Torti, Frank M Torti
Apr 4, 2012·Diseases of the Colon and Rectum·Kim EkblomJohan Hultdin
Jul 25, 2013·Critical Reviews in Oncogenesis·Suzy V Torti, Frank M Torti
Jul 3, 2013·Nutrients·Xiang Xue, Yatrik M Shah
Feb 6, 2010·World Journal of Gastroenterology : WJG·Anita C G ChuaDebbie Trinder
Jul 31, 2013·Biochimica Et Biophysica Acta·Ahmed A Alkhateeb, James R Connor
Sep 2, 2011·Women's Health·David M Robertson
Jan 19, 2011·Neurochemical Research·F Ali-RahmaniC-L Schengrund
Feb 12, 2014·Leukemia & Lymphoma·Kathrin Strasser-Weippl, Heinz Ludwig
Jan 4, 2013·Scandinavian Journal of Gastroenterology·Arne AsbergKristian Hveem
Aug 30, 2013·Expert Review of Gastroenterology & Hepatology·Pushpjeet Kanwar, Kris V Kowdley
Feb 20, 2016·Journal of Cellular and Molecular Medicine·Yang-Fan LvQiao-Nan Guo
Apr 10, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Agustin CastiellaJosé Ignacio Emparanza
Dec 27, 2011·Pathology·Itty M NadakkavukaranJohn K Olynyk
Oct 4, 2011·Biomaterials·Susan P Foy, Vinod Labhasetwar
Jul 30, 2010·International Journal of Cancer. Journal International Du Cancer·Philippe O GannonManuela M Santos
Sep 3, 2011·Cancer Science·Richard G StevensKazuo Neriishi
Mar 6, 2012·Alimentary Pharmacology & Therapeutics·A Siddique, K V Kowdley
Dec 31, 2010·International Journal of Cancer. Journal International Du Cancer·Sang Y LeeJames R Connor
Apr 8, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Silvia FargionAnna Ludovica Fracanzani
May 18, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xiaoyan LiuMing Lv
May 20, 2014·Free Radical Biology & Medicine·Laura M Bystrom, Stefano Rivella
Feb 16, 2011·Biochimica Et Biophysica Acta·Suzana KovacGraham S Baldwin
Jun 19, 2015·Nature Reviews. Cancer·Ayelet Erez, Ralph J DeBerardinis
Mar 5, 2015·Critical Reviews in Oncology/hematology·Seongseok Yun, Nicole D Vincelette
Feb 4, 2014·Cancer Letters·Oriana MarquesCarlos Lopes
May 10, 2011·Medical Hypotheses·A A OnitiloS M Sajjad
Jan 13, 2015·Medicina clínica·Albert AltésMiquel Bruguera
Apr 9, 2011·American Journal of Human Genetics·Ayelet ErezBrendan Lee
Apr 23, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Thomas P MoyerJohn B Gross

❮ Previous
Next ❯

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