PMID: 9450645Feb 5, 1998Paper

Hg(II)-induced renal cytotoxicity: in vitro and in vivo implications for the bioenergetic and oxidative status of mitochondria

Molecular and Cellular Biochemistry
A C SantosC Curti

Abstract

The effects of Hg(II) on bioenergetic and oxidative status of rat renal cortex mitochondria were evaluated both in vitro, and in vivo 1 and 24 h after treatment of animals with 5 mg HgCl2/kg i.p. The parameters assessed were mitochondrial respiration, ATP synthesis and hydrolysis, glutathione content, lipid peroxidation, protein oxidation, and activity of antioxidant enzymes. At low concentration (5 microM) and during a short incubation time, Hg(II) uncoupled oxidative phosphorylation while at slightly higher concentration or longer incubation time the ion impaired the respiratory chain. The rate of ATP synthesis and the phosphorylation potential of mitochondria were depressed, although inhibition of ATP synthesis did not exceed 50%. In vivo, respiration and ATP synthesis were not affected 1 h post-treatment, but were markedly depressed 24 h later. ATP hydrolysis by submitochondrial particle FoF1-ATPase was inhibited (also by no more than 50%) both in vitro, and in vivo 1 and 24 h post-treatment. Hg(II) induced maximum ATPase inhibition at about 1 microM concentration but did not have a strong inhibitory effect in the presence of Triton X-100. Oxidative stress was not observed in mitochondria 1 h post-treatment. However, 24 h l...Continue Reading

Citations

Mar 6, 2002·Teratology·Michael F O'HaraThomas B Knudsen
Aug 2, 2001·Journal of Applied Toxicology : JAT·M KönigsbergM C Gutiérrez-Ruiz
Nov 24, 1999·Free Radical Biology & Medicine·B QuB Halliwell
Dec 10, 2016·Inorganic Chemistry·Hridesh AgarwallaAmitava Das
Sep 21, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P R AugustiT Emanuelli
Sep 24, 2009·Mitochondrion·M A Carvalho RodriguesA C Santos

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