hGPR87 contributes to viability of human tumor cells

International Journal of Cancer. Journal International Du Cancer
Sebastian GlattWolfgang Sommergruber

Abstract

Emerging in vitro and in vivo data underline the crucial role of G-protein-coupled receptors (GPCRs) in tumorigenesis. Here, we report the contribution of hGPR87, a predicted member of the P2Y subfamily of GPCRs, to proliferation and survival of human tumor cell lines. hGPR87 mRNA transcript was found to be preferentially overexpressed in squamous cell carcinomas (SCCs) of different locations and in their lymph node metastases. Up-regulation of both, transcript and protein, was detected in samples of SCC of the lung, cervix, skin and head and neck (pharynx, larynx and epiglottis). In addition to the expression of hGPR87 in tumors which originate from stratified epithelia, we identified other hGPR87-positive tumor types including subsets of large cell and adenocarcinomas of the lung and transitional cell carcinomas of the urinary bladder. Loss of function studies using siRNA in human cancer cell lines lead to antiproliferative effects and induction of apoptosis. Like other known P2Y receptors, hGPR87 was found to be mainly located on the cell surface. The overexpression of hGPR87 preferentially in SCCs together with our functional data suggests a common molecular mechanism for SCC tumorigenesis and may provide a novel interventi...Continue Reading

References

Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D JuliusT M Jessell
Sep 2, 1999·British Journal of Cancer·P A Lazo
Oct 25, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·C L AddisonR M Strieter
Mar 10, 2001·Trends in Pharmacological Sciences·A D HowardA A Patchett
Jun 8, 2001·Genes, Chromosomes & Cancer·J PeiJ R Testa
Mar 7, 2002·Journal of the National Cancer Institute·Miriam N LangoJennifer Rubin Grandis
Sep 5, 2002·Nature Reviews. Drug Discovery·Andrew L Hopkins, Colin R Groom
Jul 8, 2003·International Journal of Cancer. Journal International Du Cancer·Huiying ZhiZhihua Liu
Jul 26, 2003·The Journal of Investigative Dermatology·Aina V H GreigGeoffrey Burnstock
Aug 24, 2004·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Yarí E Marín, Suzie Chen
Oct 20, 2004·Laboratory Investigation; a Journal of Technical Methods and Pathology·Daisuke UchidaMitsunobu Sato
Dec 25, 2004·Neuropharmacology·Mette M Rosenkilde
Sep 28, 2005·Biochemical and Biophysical Research Communications·Yosuke NonakaNorihisa Fujita
Nov 16, 2005·International Journal of Cancer. Journal International Du Cancer·Bjørn I BertelsenOle Didrik Laerum
Feb 10, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Robbert J C SlebosChristine H Chung
Mar 15, 2006·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·Christian RuppPilar Garin-Chesa
Aug 11, 2006·Traffic·Stuart J MundellAlastair W Poole
Dec 26, 2006·Current Opinion in Genetics & Development·Bryan D Spiegelberg, Heidi E Hamm
Jan 26, 2007·Nature Reviews. Cancer·Robert T Dorsam, J Silvio Gutkind
Mar 27, 2007·Biochemical and Biophysical Research Communications·Hisashi HatanakaHiroyuki Mano
Mar 30, 2007·Proceedings of the National Academy of Sciences of the United States of America·Barbara SteccaAriel Ruiz I Altaba

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Citations

Mar 13, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Ludwig G StraussAntonia Dimitrakopoulou-Strauss
Jul 9, 2013·European Journal of Pharmacology·Shoichi OchiaiNorihisa Fujita
Jan 24, 2012·Acta Pharmacologica Sinica·Rosamaria Lappano, Marcello Maggiolini
Oct 17, 2015·International Journal of Molecular Sciences·Xia ZhangYoshiyuki Kakehi
Sep 8, 2012·Biochimica Et Biophysica Acta·David N BrindleyGabor J Tigyi
May 10, 2008·Biochemical and Biophysical Research Communications·Masanori MurakamiNorihisa Fujita
Aug 26, 2010·British Journal of Pharmacology·Gabor Tigyi
Jul 12, 2011·British Journal of Pharmacology·Alba Martin-GilJesus Pintor
Jan 28, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Mukta RaniSanjay Khattri
Jun 12, 2013·International Journal of Molecular Sciences·Homare OkazoeYoshiyuki Kakehi
Oct 4, 2016·Nature Communications·Seong-Min ParkIn-Hoo Kim
Jul 26, 2017·The Journal of Biological Chemistry·Kendra S CarmonQingyun J Liu
Mar 17, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Xiang LiCaijuan Li
Jan 27, 2018·Oncotarget·Allison S CohenDavid L Morse
Sep 21, 2017·BMC Medicine·David J BirnbaumFrançois Bertucci
Dec 21, 2018·Molecular Medicine Reports·Chenggang YangXiaofeng Shi

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