Hh signaling in regeneration of the ischemic heart

Cellular and Molecular Life Sciences : CMLS
Marina Dunaeva, Johannes Waltenberger

Abstract

Myocardial infarction (MI) is caused by the occlusion of a coronary artery due to underlying atherosclerosis complicated by localized thrombosis. The blockage of blood flow leads to cardiomyocyte (CM) death in the infarcted area. Adult mammalian cardiomyocytes have little capacity to proliferate in response to injury; however, some pathways active during embryogenesis and silent during adult life are recruited in response to tissue injury. One such example is hedgehog (Hh) signaling. Hh is involved in the embryonic development of the heart and coronary vascular system. Pathological conditions including ischemia activate Hh signaling in adult tissues. This review highlights the involvement of Hh signaling in ischemic tissue regeneration with a particular emphasis on heart regeneration and discusses its potential role as a therapeutic agent.

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Citations

Jun 29, 2018·Nature Reviews. Cardiology·Jingli Cao, Kenneth D Poss
Jun 27, 2019·International Journal of Molecular Sciences·Candice ChapoulyMarie-Ange Renault
May 19, 2021·Progress in Biophysics and Molecular Biology·Abimbola J AminuHalina Dobrzynski
Jul 25, 2021·International Journal of Molecular Sciences·Abou Bakr M SalamaRiham R E Abouleisa

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Methods Mentioned

BETA
transgenic
genetic modification

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