HHV-6 infection of tonsils and adenoids in children with hypertrophy and upper airway recurrent infections

International Journal of Pediatric Otorhinolaryngology
Manola ComarCesare Campello

Abstract

Human herpes virus 6 (HHV-6), the agent of a self-limiting exanthematic disease in childhood, persists in a silent state in the secondary lymphoid organs and the reactivation is characterized by HHV-6-induced inflammatory cytokines. This study investigates the possible etiological role of HHV-6 in children affected by tonsil and adenoid hypertrophy. 55 tonsils, 80 adenoids fresh tissues and 74 blood samples were collected from 80 children (mean age 4.8 years, 43.5% female) undergoing elective tonsillectomy and/or adenoidectomy for tissue hypertrophy. Moreover, patients with <5 years old documented upper airway recurrent infections not related to relapsing of acute tonsillitis. Specific IgG antibodies and virus detection (by PCR, variant A/B enzymatic genotyping and real-time PCR) were performed. In our series, HHV-6 seroprevalence was tested at 50%. HHV-6 variant B was the unique strain finding in 25% of adenoids, in 12.7% of tonsils and in 4% of peripheral blood mononuclear cells (PBMCs). HHV-6-B was prevalent in tonsils of children affected by upper airway infections (17.8% vs 7.4%) while the adenoids represented the more frequent reservoir (30.7% vs 19.5%) in patients with hypertrophy. HHV-6 viral load was low, ranging from ...Continue Reading

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Citations

Aug 10, 2011·Proceedings of the National Academy of Sciences of the United States of America·Erin HarbertsSteven Jacobson
Nov 7, 2013·Archives of Virology·Dharam AblashiTetsushi Yoshikawa
Jun 11, 2015·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Susann SkovbjergAgnes E Wold
Oct 13, 2016·International Journal of Pediatric Otorhinolaryngology·Howard FadenKirsten St George
Oct 16, 2018·Journal of Medical Virology·Aboud KouriehUNKNOWN SPLIT study group
Aug 7, 2012·HNO·T WilhelmT Zahnert
Jun 27, 2018·Clinical and Translational Allergy·Emilia MikolaTuomas Jartti
Oct 16, 2018·Frontiers in Immunology·Afsar R NaqviSalvador Nares

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