HHV-8 Seroprevalence and Genotype Distribution in Africa, 1998⁻2017: A Systematic Review

Viruses
Elizabeth M EttaPascal O Bessong

Abstract

Human herpes virus type 8 (HHV-8) is the causative agent of Kaposi's sarcoma (KS). We systematically reviewed literature published between 1998 and 2017, according to the PRISMA guidelines, to understand the distribution of HHV-8 infection in Africa. More than two-thirds (64%) of studies reported on seroprevalence and 29.3% on genotypes; 9.5% were on both seroprevalence and genotypes. About 45% of African countries had data on HHV-8 seroprevalence exclusively, and more than half (53%) had data on either seroprevalence or genotypes. Almost half (47%) of the countries had no data on HHV-8 infection. There was high heterogeneity in the types of tests and interpretation algorithms used in determining HHV-8 seropositivity across the different studies. Generally, seroprevalence ranged from 2.0% in a group of young children in Eritrea to 100% in a small group of individuals with KS in Central African Republic, and in a larger group of individuals with KS in Morocco. Approximately 16% of studies reported on children. Difference in seroprevalence across the African regions was not significant (95% CI, χ² = 0.86; p = 0.35), although specifically a relatively significant level of infection was observed in HIV-infected children. About 38% ...Continue Reading

References

Jul 11, 1998·Oral Oncology·S R PorterN Kumar
Aug 26, 1998·International Journal of Cancer. Journal International Du Cancer·S MayamaT F Schulz
Apr 3, 1999·International Journal of Cancer. Journal International Du Cancer·A GessainG de Thé
Jun 17, 1999·The New England Journal of Medicine·F SitasR Weiss
Dec 10, 1999·International Journal of Cancer. Journal International Du Cancer·E ChokunongaD M Parkin
Dec 30, 1999·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·M EnbomA Linde
Mar 22, 2000·Sexually Transmitted Diseases·G RezzaB Ensoli
May 24, 2000·The Journal of Infectious Diseases·R J BiggarF Black
May 24, 2000·The Journal of Infectious Diseases·T M LampinenM A Williams
Jul 19, 2000·The Journal of General Virology·L AlagiozoglouL Morris
Nov 28, 2000·International Journal of Cancer. Journal International Du Cancer·E A EngelsJ L Gastwirth
Feb 15, 2001·The Journal of General Virology·Y X MengP E Pellett
Apr 21, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·C Boshoff, R A Weiss
Sep 20, 2001·The Journal of General Virology·D N KakoolaA J Davison
Oct 12, 2001·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Jianchao ZongGary S Hayward
Mar 12, 2002·JAMA : the Journal of the American Medical Association·Massimo AndreoniGiovanni Rezza
Jan 29, 2003·The Journal of Infectious Diseases·Ludo LavreysJoan K Kreiss
Apr 26, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Thomas B CampbellLovemore Gwanzura
Apr 30, 2003·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Stacia M DeSantisJanine Jason
May 17, 2003·The Journal of Infectious Diseases·Sam M MbulaiteyeRobert J Biggar
Aug 15, 2003·The Cochrane Database of Systematic Reviews·M DedicoatR Newton
May 6, 2004·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Bhavna H ChohanRhoda Ashley Morrow
Jul 10, 2004·Journal of Clinical Microbiology·M M BeyariC G Teo
Aug 4, 2004·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Jacques SimporeAntonio Angeloni

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