Sep 8, 2016

HiChIP: Efficient and sensitive analysis of protein-directed genome architecture

BioRxiv : the Preprint Server for Biology
Maxwell R MumbachHoward Y. Chang


Genome conformation is central to gene control but challenging to interrogate. Here we present HiChIP, a protein-centric chromatin conformation method. HiChIP improves the yield of conformation-informative reads by over 10-fold and lowers input requirement over 100-fold relative to ChIA-PET. HiChIP of cohesin reveals multi-scale genome architecture with greater signal to background than in situ Hi-C. Thus, HiChIP adds to the toolbox of 3D genome structure and regulation for diverse biomedical applications.

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Mentioned in this Paper

Positron-Emission Tomography
Regulation of Biological Process
Staphylococcal Protein A
Multicenter Study
CHIA gene
In Situ

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