Hidden evolutionary complexity of Nucleo-Cytoplasmic Large DNA viruses of eukaryotes.

Virology Journal
Natalya Yutin, Eugene V Koonin


The Nucleo-Cytoplasmic Large DNA Viruses (NCLDV) constitute an apparently monophyletic group that consists of at least 6 families of viruses infecting a broad variety of eukaryotic hosts. A comprehensive genome comparison and maximum-likelihood reconstruction of the NCLDV evolution revealed a set of approximately 50 conserved, core genes that could be mapped to the genome of the common ancestor of this class of eukaryotic viruses. We performed a detailed phylogenetic analysis of these core NCLDV genes and applied the constrained tree approach to show that the majority of the core genes are unlikely to be monophyletic. Several of the core genes have been independently acquired from different sources by different NCLDV lineages whereas for the majority of these genes displacement by homologs from cellular organisms in one or more groups of the NCLDV was demonstrated. A detailed study of the evolution of the genomic core of the NCLDV reveals substantial complexity and diversity of evolutionary scenarios that was largely unsuspected previously. The phylogenetic coherence between the core genes is sufficient to validate the hypothesis on the evolution of all NCLDV from a common ancestral virus although the set of ancestral genes mig...Continue Reading


Jan 1, 1995·Virus Genes·K C Sonntag, G Darai
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·R JainJ A Lake
Jan 8, 2000·The Journal of Biological Chemistry·C A Lackner, R C Condit
Sep 7, 2001·Annual Review of Microbiology·E V KooninL Aravind
Nov 2, 2001·Journal of Virology·L M IyerE V Koonin
Jun 25, 2002·Systematic Biology·Hidetoshi Shimodaira
Jun 12, 2003·Research in Microbiology·Jonathan FiléeJacqueline Laurent
Oct 8, 2003·Systematic Biology·Stéphane Guindon, Olivier Gascuel
Nov 18, 2003·Annual Review of Genetics·James L Van Etten
Mar 23, 2004·Nucleic Acids Research·Robert C Edgar
Jun 30, 2004·BMC Evolutionary Biology·Gangolf JobbKorbinian Strimmer
Oct 16, 2004·Science·Didier RaoultJean-Michel Claverie
Feb 24, 2006·Virus Research·Lakshminarayan M IyerL Aravind
Sep 21, 2006·Biology Direct·Eugene V KooninValerian V Dolja
Feb 12, 2008·Current Opinion in Structural Biology·John M Pascal
May 9, 2008·Molecular Biology and Evolution·Natalya YutinEugene V Koonin
Jul 5, 2008·Genome Biology·Adam MonierHiroyuki Ogata
Aug 5, 2009·Environmental Microbiology·Karen D WeynbergWilliam H Wilson
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Tatiana G SenkevichBernard Moss
Nov 10, 2009·Journal of Molecular Biology·William J Lane, Seth A Darst
Dec 17, 2009·Proceedings of the National Academy of Sciences of the United States of America·Mickaël BoyerDidier Raoult
Feb 6, 2010·FEMS Microbiology Reviews·Claire MolinerDidier Raoult
Jun 17, 2010·Intervirology·Eugene V Koonin, Natalya Yutin
Jun 17, 2010·Intervirology·Didier Raoult, Mickael Boyer
Jun 17, 2010·Intervirology·Philippe Colson, Didier Raoult
Aug 10, 2010·Annual Review of Microbiology·James L Van EttenDavid D Dunigan
Oct 27, 2010·Proceedings of the National Academy of Sciences of the United States of America·Matthias G FischerCurtis A Suttle
Mar 12, 2011·Environmental Microbiology·Vincent ThomasGilbert Greub
Oct 12, 2011·Proceedings of the National Academy of Sciences of the United States of America·Defne ArslanJean-Michel Claverie
Dec 6, 2011·Nucleic Acids Research·Eric W SayersJian Ye

❮ Previous
Next ❯


Apr 12, 2013·The ISME Journal·Pascal HingampHiroyuki Ogata
Apr 9, 2013·Genome Biology and Evolution·Stephanie MichelyGwenaël Piganeau
Dec 18, 2013·Virology Journal·Xiaohong HuangQiwei Qin
Oct 24, 2013·Biology Direct·Natalya Yutin, Eugene V Koonin
Dec 3, 2013·Virus Genes·Niyaz YoosufPhilippe Colson
Oct 11, 2013·Molecular Biology and Evolution·Mark P ZwartSantiago F Elena
Jul 11, 2013·Oxidative Medicine and Cellular Longevity·Khushwant S Bhullar, H P Vasantha Rupasinghe
Jun 28, 2014·Nature Communications·Florian MaumusGuillaume Blanc
Jul 3, 2013·Archives of Virology·Philippe ColsonDidier Raoult
Feb 24, 2016·Frontiers in Microbiology·Samia BenamarBernard La Scola
Feb 2, 2016·Current Opinion in Microbiology·Vikas SharmaDidier Raoult
Jul 31, 2013·Current Opinion in Virology·Jonathan Filée
Jul 16, 2013·Current Opinion in Virology·Eugene V Koonin, Valerian V Dolja
Mar 12, 2016·Studies in History and Philosophy of Biological and Biomedical Sciences·Eugene V Koonin, Petro Starokadomskyy
Jun 23, 2015·Cellular Microbiology·Cristina SuarezJacomine Krijnse Locker
Jun 12, 2013·Cellular Microbiology·Cristina SuárezJacomine Krijnse Locker
Feb 20, 2016·Current Opinion in Microbiology·Patrick Forterre, Morgan Gaïa
Apr 6, 2016·Frontiers in Microbiology·Sarah AherfiDidier Raoult
Apr 5, 2016·Current Opinion in Microbiology·Romain Blanc-Mathieu, Hiroyuki Ogata
Aug 12, 2014·Virology·Sarah AherfiPhilippe Colson
Mar 3, 2015·Annals of the New York Academy of Sciences·Eugene V KooninNatalya Yutin
Sep 2, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·David Moreira, Purificación López-García
Aug 25, 2015·Frontiers in Microbiology·Vikas SharmaDidier Raoult
Mar 15, 2015·Virology·Gerhard ThielJames L Van Etten
Jun 5, 2015·Frontiers in Microbiology·Vikas SharmaDidier Raoult
Mar 17, 2015·Virology·Eugene V KooninMart Krupovic
Jan 22, 2015·Molecular Biology and Evolution·Kirill UstyantsevGeorgy Smyshlyaev
Apr 4, 2015·Genome Biology and Evolution·Mart KrupovicNeal S Young
Nov 24, 2012·Journal of Virological Methods·Lea HošnjakMario Poljak
Aug 19, 2014·Trends in Microbiology·Patrick ForterreDavid Prangishvili
Dec 24, 2014·Nature Reviews. Microbiology·Mart Krupovic, Eugene V Koonin
May 15, 2016·Journal of Theoretical Biology·Víctor Serrano-SolísMarco V José
Jul 5, 2016·Frontiers in Microbiology·Patrick W LaffyThomas Rattei

❮ Previous
Next ❯

Methods Mentioned

gene exchange

Software Mentioned


Related Concepts

Related Feeds

CRISPR Ribonucleases Deactivation

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on mechanisms that underlie deactivation of CRISPR ribonucleases. Here is the latest research.