PMID: 8947599Nov 1, 1996Paper

Hierarchic T-cell help to non-linked B-cell epitopes

Scandinavian Journal of Immunology
N H BronsC P Muller

Abstract

The induction of antibodies against peptides requires the presence of a T helper cell epitope. In the absence of an added T-cell epitope only 10% of the mice, or less depending on the strain, gave an antibody response to a series of peptides of the measles virus (MV) fusion (F) protein. After coimmunization with a non-covalently coupled T-cell epitope more than 60% of the peptides became immunogenic. Considerable differences became apparent when BALB/c mice were immunized with peptides in the presence of different T-cell epitopes. An immunodominant T-cell epitope of the MV-F protein was more efficient than a subdominant or a cryptic T-cell epitope in providing help to a non-linked B-cell epitope. There is both a ranking order of the amount of help which B-cell epitopes require and a ranking order for the help T-cell epitopes are able to provide. The capability of a T-cell epitope to provide help to a B-cell epitope correlated with its own immunogenicity, i.e. the intensity of the antibody response to the peptide representing the T-cell epitope. The data suggest that for each MHC class II allele there is an optimal T-cell epitope which can provide help to a maximal number of B-cell epitopes and that such a peptide can be identif...Continue Reading

Citations

Sep 13, 2011·Protein Engineering, Design & Selection : PEDS·Margaret E AckermanK Dane Wittrup
Aug 20, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K L BøghC B Madsen
Mar 1, 2012·Journal of Agricultural and Food Chemistry·Katrine L BøghCharlotte B Madsen
Dec 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Masanori OndaIra Pastan
Oct 8, 2020·Current Pharmaceutical Design·Maryam DashtiahangarSamaneh Ghasemali

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