Hierarchical assembly may be a way to make large information-rich structures

Soft Matter
Stephen Whitelam

Abstract

Self-assembly in the laboratory can now yield 'information-rich' nanostructures in which each component is of a distinct type and has a defined spatial position. Ensuring the thermodynamic stability of such structures requires inter-component interaction energies to increase logarithmically with structure size, in order to counter the entropy gained upon mixing component types in solution. However, self-assembly in the presence of strong interactions results in general in kinetic trapping, so suggesting a limit to the size of an (equilibrium) structure that can be self-assembled from distinguishable components. Here we study numerically a two-dimensional hierarchical assembly scheme already considered in experiment. We show that this scheme is immune to the kinetic traps associated with strong 'native' interactions (interactions designed to stabilize the intended structure), and so, in principle, offers a way to make large information-rich structures. In this scheme the size of an assembled structure scales exponentially with the stage of assembly, and assembly can continue as long as random motion is able to bring structures into contact. The resulting superstructure could provide a template for building in the third dimension...Continue Reading

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Citations

Feb 11, 2016·Journal of the American Chemical Society·William M Jacobs, Daan Frenkel
Sep 26, 2015·Soft Matter·William M Jacobs, Daan Frenkel
Jul 6, 2016·Soft Matter·Aleks Reinhardt, Daan Frenkel
Aug 24, 2016·Chemical Reviews·Michael A BolesDmitri V Talapin
Jan 15, 2016·Faraday Discussions·Aleks ReinhardtDaan Frenkel
Feb 6, 2020·ELife·Florian M GartnerErwin Frey
May 18, 2016·Chembiochem : a European Journal of Chemical Biology·Wolfgang Pfeifer, Barbara Saccà
Mar 9, 2021·ACS Nano·Farzaneh MohajeraniMichael F Hagan
May 19, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Shijin ZhangYe Zhang

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