Hierarchical Connectome Modes and Critical State Jointly Maximize Human Brain Functional Diversity

Physical Review Letters
Rong WangChangsong Zhou

Abstract

The brain requires diverse segregated and integrated processing to perform normal functions in terms of anatomical structure and self-organized dynamics with critical features, but the fundamental relationships between the complex structural connectome, critical state, and functional diversity remain unknown. Herein, we extend the eigenmode analysis to investigate the joint contribution of hierarchical modular structural organization and critical state to brain functional diversity. We show that the structural modes inherent to the hierarchical modular structural connectome allow a nested functional segregation and integration across multiple spatiotemporal scales. The real brain hierarchical modular organization provides large structural capacity for diverse functional interactions, which are generated by sequentially activating and recruiting the hierarchical connectome modes, and the critical state can best explore the capacity to maximize the functional diversity. Our results reveal structural and dynamical mechanisms that jointly support a balanced segregated and integrated brain processing with diverse functional interactions, and they also shed light on dysfunctional segregation and integration in neurodegenerative disea...Continue Reading

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Citations

Mar 14, 2020·Physical Review Letters·Rico BernerEckehard Schöll
Dec 18, 2020·Physical Review. E·Nahid SafariMarzieh Zare
Jan 18, 2021·NeuroImage·James C PangJames A Roberts
Jun 3, 2021·Proceedings of the National Academy of Sciences of the United States of America·Rong WangChangsong Zhou
Aug 3, 2021·Frontiers in Computational Neuroscience·Carlos Coronel-OliverosPatricio Orio
Nov 19, 2021·PloS One·Majid SaberiGholamreza Jafari

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