Hierarchical CuInS2 -based heterostructure: Application for photocathodic bioanalysis of sarcosine

Biosensors & Bioelectronics
Xin-Yuan JiangHong-Yuan Chen

Abstract

In this study, on the basis of hierarchical CuInS2-based heterostructure, a novel cathodic photoelectrochemical (PEC) enzymatic bioanalysis of the sarcosine detection was reported. Specifically, heterostructured CuInS2/NiO/ITO photocathode was prepared and sarcosine oxidases (SOx) were integrated for the construction of the enzymatic biosensor. In the bioanalysis, the O2-dependent suppression of the cathodic photocurrent can be observed due to the competition between the as-fabricated O2-sensitive photocathode and the SOx-catalytic event toward O2 reduction. Based on the sarcosine-controlled O2 concentration, a novel photocathodic enzymatic biosensor could be realized for the sensitive and specific sarcosine detection. This work manifested the great potential of CuInS2-based heterostructure as a novel platform for future PEC bioanalytical development and also a PEC method for sarcosine detection, which could be easily extended to numerous other enzymatic systems and to our knowledge has not been reported. This work is expected to stimulate more interest in the design and implementation of numerous CuInS2-based heterostructured photocathodic enzymatic sensing.

Citations

May 6, 2019·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·C S PundirParveen Kumar
Jun 13, 2020·Sensors·Melisa Del BarrioMarcos Pita

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